Clinical Significance of Oral Urease in Diagnosis of Helicobacter Pylori Infection by [13C]urea Breath Test

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 2001 Aug 18

PMID 11508681

Citations 13

Authors

N J Peng

K H Lai

R S Liu

S C Lee

D G Tsay

C C Lo

H H Tseng

W K Huang

G H Lo

P I Hsu

Affiliations

Soon will be listed here.

Abstract

This study was performed to evaluate the effect of oral flora on [13C]urea breath test in detecting H. pylori infection and find an optimal method and timing for sample collection. Forty-five volunteers were included in this study. The [13C]urea breath test was performed using mouthwash, endoscopic administration, and conventional methods. According to the receiver-operating characteristic curves, the earliest optimal time for discriminating H. pylori-positive and H. pylori-negative patients was at 25 min with the mouthwash method with 78% sensitivity and 82% specificity, at 2 min with the endoscopic administration method with 100% sensitivity and 100% specificity, and at 6 min with the conventional method with 100% sensitivity and 95% specificity. The study shows a significant effect of oral urease on the results of the [13C]urea breath test. The timing of sampling collection can be shortened to 6 min with the conventional method or to 2 min through endoscopic administration.

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