Signaling by the JNK Group of MAP Kinases. C-jun N-terminal Kinase

Overview

Journal J Clin Immunol

Publisher Springer

Specialty Allergy & Immunology

Date 2001 Aug 17

PMID 11506194

Citations 21

Authors

C Dong

R J Davis

R A Flavell

Affiliations

Soon will be listed here.

Abstract

c-Jun N-terminal kinase (JNK) is one of the several main MAP kinase groups identified in mammals. Original studies by use of Jurkat T cells implicated JNK in T cell activation and interleukin (IL-2) expression. Recent advances using mouse genetic approaches have revealed novel functions of this pathway in primary mouse T cells. JNK is not essential for T-cell activation; instead, it is required for helper T differentiation into effector cells and their cytokine production. In this review, we summarize these advances in understanding the expression, function, and regulation of the JNK pathway in T-lymphocyte activation and differentiation.

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