Coordination of Ca2+ Signalling by NAADP

Overview

Journal Trends Biochem Sci

Specialty Biochemistry

Date 2001 Aug 16

PMID 11504624

Citations 53

Authors

S Patel

G C Churchill

A Galione

Affiliations

Soon will be listed here.

Abstract

Nicotinic acid adenine dinucleotide phosphate (NAADP) mobilizes intracellular Ca2+ stores in several cell types. Ample evidence suggests that NAADP activates intracellular Ca2+ channels distinct from those that are sensitive to inositol trisphosphate and ryanodine/cyclic ADP-ribose. Recent studies in intact cells have demonstrated functional coupling ('channel chatter') between Ca2+ release pathways mediated by NAADP, inositol trisphosphate and cyclic ADP-ribose. Thus, NAADP is probably an important determinant in shaping cytosolic Ca2+ signals.

Citing Articles

Regulation of autophagy by perilysosomal calcium: a new player in β-cell lipotoxicity.

Nguyen H, Wiederkehr A, Wollheim C, Park K Exp Mol Med. 2024; 56(2):273-288.

PMID: 38297165 PMC: 10907728. DOI: 10.1038/s12276-024-01161-x.

Two-pore channel-2 and inositol trisphosphate receptors coordinate Ca signals between lysosomes and the endoplasmic reticulum.

Yuan Y, Arige V, Saito R, Mu Q, Brailoiu G, Pereira G Cell Rep. 2023; 43(1):113628.

PMID: 38160394 PMC: 10931537. DOI: 10.1016/j.celrep.2023.113628.

Unraveling the Cave: A Seventy-Year Journey into the Caveolar Network, Cellular Signaling, and Human Disease.

DAlessio A Cells. 2023; 12(23).

PMID: 38067108 PMC: 10705299. DOI: 10.3390/cells12232680.

Segregated cation flux by TPC2 biases Ca signaling through lysosomes.

Yuan Y, Jaslan D, Rahman T, Bolsover S, Arige V, Wagner 2nd L Nat Commun. 2022; 13(1):4481.

PMID: 35918320 PMC: 9346130. DOI: 10.1038/s41467-022-31959-0.

NAADP-Mediated Ca Signalling.

Galione A, Davis L, Martucci L, Morgan A Handb Exp Pharmacol. 2022; 278:3-34.

PMID: 35879580 DOI: 10.1007/164_2022_607.