Correlation Between Histone Lysine Methylation and Developmental Changes at the Chicken Beta-globin Locus

Overview

Journal Science

Specialty Science

Date 2001 Aug 11

PMID 11498546

Citations 211

Authors

M D Litt

M Simpson

M Gaszner

C D Allis

G Felsenfeld

Affiliations

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Abstract

Methylation of histones at specific residues plays an important role in transcriptional regulation. Chromatin immunoprecipitation of dimethylated lysine 9 on histone H3 across 53 kilobases of the chicken beta-globin locus during erythropoiesis shows an almost complete anticorrelation between regions of elevated lysine 9 methylation and acetylation. Lysine 9 is methylated most over constitutive condensed chromatin and developmentally inactive globin genes. In contrast, lysine 4 methylation of histone H3 correlates with H3 acetylation. These results lead us to propose a mechanism by which the insulator in the beta-globin locus can protect the globin genes from being silenced by adjacent condensed chromatin.

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