Effects of Linalool on Glutamate Release and Uptake in Mouse Cortical Synaptosomes

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 2001 Aug 10

PMID 11495541

Citations 28

Authors

L F Silva Brum

T Emanuelli

D O Souza

E Elisabetsky

Affiliations

Soon will be listed here.

Abstract

Linalool, a monoterpene compound prevalent in essential oil of plant species traditionally used as sedatives, has been characterized as anticonvulsant in several experimental models. Linalool inhibits the binding of [3H]glutamate and [3H]dizocilpine to brain cortical membranes, indicating a participation of the glutamatergic transmission its mechanism of action. In this study, we investigated the effects of linalool on [3H]glutamate release (basal and potassium-stimulated) and [3H]glutamate uptake in mice cortical synaptosomes. Linalool significantly reduced potassium-stimulated glutamate release as well as glutamate uptake, not interfering with basal glutamate release. The data indicates that linalool may interfere with several relevant elements of the glutamatergic transmission, including detriment of the K+-stimulated glutamate release.

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