Microsatellite Polymorphism of the MICA Gene and Susceptibility to Rheumatoid Arthritis

Overview

Journal Clin Exp Rheumatol

Specialty Rheumatology

Date 2001 Aug 9

PMID 11491503

Citations 8

Authors

D P Singal

J Li

G Zhang

Affiliations

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Abstract

We examined the role of MICA gene alleles in susceptibility to rheumatoid arthritis (RA). Ninety adult Caucasian patients with classical seropositive RA and 85 normal healthy Caucasian subjects from the same geographical area were typed for microsatellite repeat polymorphism in the transmembrane region of the MICA gene by the polymerase chain reaction. The results show that the MICA allele 6 may confer protection from the development of RA.

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