Treatment of Hypernatraemic Dehydration in Infancy

Overview

Journal Arch Dis Child

Specialty Pediatrics

Date 1975 Mar 1

PMID 1147650

Citations 12

Authors

A Banister

G W HATCHER

Affiliations

Soon will be listed here.

Abstract

Thirty-eight infants with severe hyperosmolar dehydration and hypernatraemia were treated, using three regimens of intravenous fluids: A. 1/2 normal saline, given fast; B.1/2 normal saline given slowly; C. 1/5 normal saline. 28 of the infants were studied in a treatment trial, and it is concluded tha 0-18% saline in 4-3% dextrose, with the early addition of potassium given at a rate of 100 ml/kg estimated rehydrated weight per 24 hours gives satisfactory rehydration within 48 hours, with little risk of convulsions.

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Hypernatraemia in the first few days: is the incidence rising?.

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Effects of hypernatraemia in the central nervous system and its therapy in rats and rabbits.

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Controlled fall in natremia in hypertonic dehydration: possible avoidance of rehydration seizures.

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References

WEIL W, WALLACE W . Hypertonic dehydration in infancy. Pediatrics. 1956; 17(2):171-83. View

DELEON A, BERGSTROM W . HYPERTONIC DEHYDRATION. N Y State J Med. 1964; 64:2157-60. View

Kim J, BORGES W, HOLLIDAY M . Correlation between RBC osmotic fragility and serum sodium. Am J Dis Child. 1962; 104:281-8. DOI: 10.1001/archpedi.1962.02080030283011. View

MOLL F, Skinner A . Hypernatremia accompanying infant diarrhea. AMA J Dis Child. 1956; 92(6):562-75. DOI: 10.1001/archpedi.1956.02060030556004. View

McDowell M, WOLF A, Steer A . Osmotic volumes of distribution; idiogenic changes in osmotic pressure associated with administration of hypertonic solutions. Am J Physiol. 1955; 180(3):545-58. DOI: 10.1152/ajplegacy.1955.180.3.545. View

Houston I, Evans R . Prognosis of the neurological complications of acute hypernatraemia. Lancet. 1967; 2(7531):1385-9. DOI: 10.1016/s0140-6736(67)93022-x. View

Stevenson R, BOWYER F . Hyperglycemia with hyperosmolal dehydration in nondiabetic infants. J Pediatr. 1970; 77(5):818-23. DOI: 10.1016/s0022-3476(70)80241-4. View

Ahmed I . Hypernatraemia in diarrhoeal infants in Lagos. Arch Dis Child. 1970; 45(239):97-103. PMC: 2020418. DOI: 10.1136/adc.45.239.97. View

Hogan G, DODGE P, Gill S, Master S, Sotos J . Pathogenesis of seizures occurring during restoration of plasma tonicity to normal in animals previously chronically hypernatremic. Pediatrics. 1969; 43(1):54-64. View

10.

Bruck E, Abal G, ACETO Jr T . Therapy of infants with hypertonic dehydration due to diarrhea. A controlled study of clinical, chemical, and pathophysiological response to two types of therapeutic fluid regimen, with evaluation of late sequelae. Am J Dis Child. 1968; 115(3):281-301. DOI: 10.1001/archpedi.1968.02100010283001. View

11.

Boyer J, Gill G, EPSTEIN F . Hyperglycemia and hyperosmolality complicating peritoneal dialysis. Ann Intern Med. 1967; 67(3):568-72. DOI: 10.7326/0003-4819-67-3-568. View

12.

STICKLER G . Warning regarding administration of fluids. Clin Pediatr (Phila). 1967; 6(6):323. DOI: 10.1177/000992286700600604. View

13.

DE HEESE H, Tonin C, BOWIE M, Evans A . Management of metabolic acidosis in acute gastro-enteritis. Br Med J. 1966; 2(5506):144-6. PMC: 1943682. DOI: 10.1136/bmj.2.5506.144. View

14.

LOGOTHETIS J . Neurologic effects of water and sodium disturbances. I. General mechanisms; hypernatremic syndromes. Postgrad Med. 1966; 40(4):408-17. DOI: 10.1080/00325481.1966.11695978. View