Calculation of the Hydrophobicity of Platinum Drugs

Overview

Journal J Med Chem

Publisher American Chemical Society

Specialty Chemistry

Date 2001 Jul 21

PMID 11462986

Citations 12

Authors

J A Platts

D E Hibbs

T W Hambley

M D Hall

Affiliations

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Abstract

Models of the hydrophobicity of platinum drugs based on exposed surface areas of polar and nonpolar atoms are presented. For a total of 24 log P(oct) data, the best model resulted in a standard deviation of 0.35 over a range of more than 4 log units, with regression coefficients in broad agreement with previous models of log P(oct) for organic molecules. This model is used to compare log P(oct) to cell uptake for five platinum drugs and hence to establish an exponential relation between these parameters.

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