Responses of Baboon Cerebral and Extracerebral Arteries to Prostacyclin and Prostaglandin Endoperoxide in Vitro and in Vivo

Overview

Journal J Neurol Neurosurg Psychiatry

Publisher BMJ Publishing Group

Specialties Neurology
Neurosurgery
Psychiatry

Date 1979 Aug 1

PMID 114606

Citations 5

Authors

D A JARMAN

G H DU BOULAY

B Kendall

D J Boullin

Affiliations

Soon will be listed here.

Abstract

The responses of baboon cerebral and extracerebral arteries to prostaglandin endoperoxide (PGH2) and prostacyclin (PGI2) were investigated on isolated arteries and in vivo by serial angiography. Both PGH2 and PGI2 could produce dose-dependent contraction or relaxation of isolated arteries. PGH2 induced relaxation was indicative of prostacyclin synthetase activity, the enzyme which converts PGH2 to PGI2. In isolated arteries tested one to four hours post mortem only the vertebral artery showed prostacyclin synthetase activity. Thus PGH2 induced contraction of cerebral arteries may be indicative of a physiological function. Vasomotor tone may in part be the result of a balance between PGH2 constriction and PGI2 dilatation. In vivo PGI2 infusion caused pronounced and prolonged dilatation of cerebral arteries, which lasted longer than the cardiovascular changes. As PGI2 is the most potent cerebral vasodilator drug tested, it may be of clinical use in the treatment of cerebral vasospasm.

Citing Articles

The calibre of cerebral arteries of the rat studied by carotid angiography: a model system for studying the aetiology of human cerebral arterial constriction after aneurysmal rupture.

Boullin D, Aitken V, DU BOULAY G, Tagari P Neuroradiology. 1981; 21(5):245-52.

PMID: 7266859 DOI: 10.1007/BF02100154.

The effect of prostacyclin on cerebral vasospasm. An experimental study.

Quintana L, Konda R, Ishibashi Y, Yoshimoto T, Suzuki J Acta Neurochir (Wien). 1982; 62(3-4):187-93.

PMID: 7048862 DOI: 10.1007/BF01403623.

Effect of epoprostenol (prostacyclin, PGI2) on cerebral blood flow in man.

Brown M, Pickles H J Neurol Neurosurg Psychiatry. 1982; 45(11):1033-6.

PMID: 6816907 PMC: 491641. DOI: 10.1136/jnnp.45.11.1033.

The effect of intravenous epoprostenol (prostacyclin, PGI2) on cerebral blood flow and cardiac output in man.

Cook P, Maidment C, Dandona P, HUTTON R, James I Br J Clin Pharmacol. 1983; 16(6):707-11.

PMID: 6362696 PMC: 1428346. DOI: 10.1111/j.1365-2125.1983.tb02245.x.

Cerebral vasospasm as a complication of aneurysmal subarachnoid hemorrhage: a brief review.

Spallone A Ital J Neurol Sci. 1985; 6(1):19-26.

PMID: 3888914 DOI: 10.1007/BF02229213.

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