Transcriptional Reprogramming During T Helper Cell Differentiation

Overview

Journal Immunol Res

Specialty Allergy & Immunology

Date 2001 Jul 11

PMID 11444384

Citations 2

Authors

T M Aune

Affiliations

Soon will be listed here.

Abstract

Our laboratory employs reporter transgenic mice as model systems to study the transcriptional reprogramming that accompanies T helper cell differentiation. These studies demonstrate that changes in the activity of simple transcriptional elements associated with the IFN-gamma gene can recapitulate alterations in gene expression. In addition, our studies have revealed a key role for the transcription factor, CAMP response element binding protein (CREB), in the protection of differentiating T cells from apoptosis. Together, these findings further our understanding of the logic employed by T cells to alter gene expression profiles in response to differentiation signals.

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