Genome-wide Gene Expression Profiles of the Developing Mouse Hippocampus

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2001 Jul 5

PMID 11438693

Citations 84

Authors

M Mody

Y Cao

Z Cui

K Y Tay

A Shyong

E Shimizu

K Pham

P Schultz

D Welsh

J Z Tsien

Affiliations

Soon will be listed here.

Abstract

We have analyzed the developmental molecular programs of the mouse hippocampus, a cortical structure critical for learning and memory, by means of large-scale DNA microarray techniques. Of 11,000 genes and expressed sequence tags examined, 1,926 showed dynamic changes during hippocampal development from embryonic day 16 to postnatal day 30. Gene-cluster analysis was used to group these genes into 16 distinct clusters with striking patterns that appear to correlate with major developmental hallmarks and cellular events. These include genes involved in neuronal proliferation, differentiation, and synapse formation. A complete list of the transcriptional changes has been compiled into a comprehensive gene profile database (http://BrainGenomics.Princeton.edu), which should prove valuable in advancing our understanding of the molecular and genetic programs underlying both the development and the functions of the mammalian brain.

Citing Articles

RNA helicase MOV10 suppresses fear memory and dendritic arborization and regulates microtubule dynamics in hippocampal neurons.

Shilikbay T, Nawaz A, Doon M, Ceman S BMC Biol. 2025; 23(1):36.

PMID: 39915816 PMC: 11803958. DOI: 10.1186/s12915-025-02138-6.

Individual NMDA receptor GluN2 subunit signaling domains differentially regulate the postnatal maturation of hippocampal excitatory synaptic transmission and plasticity but not dendritic morphology.

Keith R, Wild G, Keith M, Chen D, Pack S, Dumas T Synapse. 2024; 78(4):e22292.

PMID: 38813758 PMC: 11141731. DOI: 10.1002/syn.22292.

Modulation of Microglial Function by ATP-Gated P2X7 Receptors: Studies in Rat, Mice and Human.

Tewari M, Michalski S, Egan T Cells. 2024; 13(2).

PMID: 38247852 PMC: 10814008. DOI: 10.3390/cells13020161.

Regulation of cerebellar network development by granule cells and their molecules.

Kim M, Jun S, Park H, Tanaka-Yamamoto K, Yamamoto Y Front Mol Neurosci. 2023; 16:1236015.

PMID: 37520428 PMC: 10375027. DOI: 10.3389/fnmol.2023.1236015.

Genetically encoded phosphatidylserine biosensor for in vitro, ex vivo and in vivo labelling.

Dirvelyte E, Bujanauskiene D, Jankaityte E, Daugelaviciene N, Kisieliute U, Nagula I Cell Mol Biol Lett. 2023; 28(1):59.

PMID: 37501184 PMC: 10373266. DOI: 10.1186/s11658-023-00472-7.

References

Kelly J, Dodd J . Cholecystokinin and gastrin as transmitters in the mammalian central nervous system. Adv Biochem Psychopharmacol. 1981; 28:133-44. View

Jiang C, Tsien J, Schultz P, Hu Y . The effects of aging on gene expression in the hypothalamus and cortex of mice. Proc Natl Acad Sci U S A. 2001; 98(4):1930-4. PMC: 29359. DOI: 10.1073/pnas.98.4.1930. View

Pokorny J, Yamamoto T . Postnatal ontogenesis of hippocampal CA1 area in rats. II. Development of ultrastructure in stratum lacunosum and moleculare. Brain Res Bull. 1981; 7(2):121-30. DOI: 10.1016/0361-9230(81)90076-9. View

Gower H, Moore S, Dickson G, Elsom V, Nayak R, Walsh F . Cloning and characterization of a myoblast cell surface antigen defined by 24.1D5 monoclonal antibody. Development. 1989; 105(4):723-31. DOI: 10.1242/dev.105.4.723. View

Jessell T, Hynes M, Dodd J . Carbohydrates and carbohydrate-binding proteins in the nervous system. Annu Rev Neurosci. 1990; 13:227-55. DOI: 10.1146/annurev.ne.13.030190.001303. View

Bennett M, Calakos N, Kreiner T, Scheller R . Synaptic vesicle membrane proteins interact to form a multimeric complex. J Cell Biol. 1992; 116(3):761-75. PMC: 2289316. DOI: 10.1083/jcb.116.3.761. View

Bliss T, Collingridge G . A synaptic model of memory: long-term potentiation in the hippocampus. Nature. 1993; 361(6407):31-9. DOI: 10.1038/361031a0. View

Hata Y, Slaughter C, Sudhof T . Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin. Nature. 1993; 366(6453):347-51. DOI: 10.1038/366347a0. View

Mulkey R, Endo S, Shenolikar S, Malenka R . Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression. Nature. 1994; 369(6480):486-8. DOI: 10.1038/369486a0. View

10.

Doenecke D, Albig W, Bouterfa H, Drabent B . Organization and expression of H1 histone and H1 replacement histone genes. J Cell Biochem. 1994; 54(4):423-31. DOI: 10.1002/jcb.240540409. View

11.

Bear M, Malenka R . Synaptic plasticity: LTP and LTD. Curr Opin Neurobiol. 1994; 4(3):389-99. DOI: 10.1016/0959-4388(94)90101-5. View

12.

Faraonio R, Minopoli G, Porcellini A, Costanzo F, Cimino F, Russo T . The DNA sequence encompassing the transcription start site of a TATA-less promoter contains enough information to drive neuron-specific transcription. Nucleic Acids Res. 1994; 22(23):4876-83. PMC: 523751. DOI: 10.1093/nar/22.23.4876. View

13.

Sherr C . D-type cyclins. Trends Biochem Sci. 1995; 20(5):187-90. DOI: 10.1016/s0968-0004(00)89005-2. View

14.

Calakos N, Scheller R . Synaptic vesicle biogenesis, docking, and fusion: a molecular description. Physiol Rev. 1996; 76(1):1-29. DOI: 10.1152/physrev.1996.76.1.1. View

15.

Horne M, Goolsby G, Donaldson K, Tran D, Neubauer M, Wahl A . Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression. J Biol Chem. 1996; 271(11):6050-61. DOI: 10.1074/jbc.271.11.6050. View

16.

Baldwin T, Fazeli M, Doherty P, Walsh F . Elucidation of the molecular actions of NCAM and structurally related cell adhesion molecules. J Cell Biochem. 1996; 61(4):502-13. DOI: 10.1002/(sici)1097-4644(19960616)61:4<502::aid-jcb3>3.0.co;2-s. View

17.

Tsien J, Huerta P, Tonegawa S . The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell. 1996; 87(7):1327-38. DOI: 10.1016/s0092-8674(00)81827-9. View

18.

Doenecke D, Albig W, Bode C, Drabent B, Franke K, Gavenis K . Histones: genetic diversity and tissue-specific gene expression. Histochem Cell Biol. 1997; 107(1):1-10. DOI: 10.1007/s004180050083. View

19.

Glatz J, Van der Vusse G . Cellular fatty acid-binding proteins: their function and physiological significance. Prog Lipid Res. 1996; 35(3):243-82. DOI: 10.1016/s0163-7827(96)00006-9. View

20.

Weiner J, Chun J . Png-1, a nervous system-specific zinc finger gene, identifies regions containing postmitotic neurons during mammalian embryonic development. J Comp Neurol. 1997; 381(2):130-42. DOI: 10.1002/(sici)1096-9861(19970505)381:2<130::aid-cne2>3.0.co;2-4. View