Translational Control by CPEB: a Means to the End

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2001 Jul 4

PMID 11433366

Citations 245

Authors

R Mendez

J D Richter

Affiliations

Soon will be listed here.

Abstract

The regulated translation of messenger RNA is essential for cell-cycle progression, establishment of the body plan during early development, and modulation of key activities in the central nervous system. Cytoplasmic polyadenylation, which is one mechanism of controlling translation, is driven by CPEB--a highly conserved, sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element, and modulates translational repression and mRNA localization. What are the features and functions of this multifaceted protein?

Citing Articles

CPEB3 can regulate seizure susceptibility by inhibiting the transcriptional activity of STAT3 on NMDARs expression.

You Z, Huang C, Wei F, Li J, Liu Y, Liu X Mol Med. 2025; 31(1):77.

PMID: 39994587 PMC: 11852879. DOI: 10.1186/s10020-025-01136-2.

MARTRE family proteins negatively regulate CCR4-NOT activity to protect poly(A) tail length and promote translation of maternal mRNA.

Yang J, Bu J, Liu B, Liu Y, Zhang Z, Li Z Nat Commun. 2025; 16(1):248.

PMID: 39747175 PMC: 11696134. DOI: 10.1038/s41467-024-55610-2.

Effect of Gossypol on Gene Expression in Swine Granulosa Cells.

Hong M, Kim H, Choi S, Sharma N, Lee S Toxins (Basel). 2024; 16(10).

PMID: 39453212 PMC: 11511463. DOI: 10.3390/toxins16100436.

High-sensitivity whole-mount in situ Hybridization of Mouse Oocytes and Embryos Visualizes the Super-resolution Structures and Distributions of mRNA Molecules.

Sanada T, Kotani T Biol Proced Online. 2024; 26(1):23.

PMID: 38987687 PMC: 11234658. DOI: 10.1186/s12575-024-00250-5.

Core-shell model of the clusters of CPEB4 isoforms preceding liquid-liquid phase separation.

Oranges M, Jash C, Golani G, Seal M, Cohen S, Rosenhek-Goldian I Biophys J. 2024; 123(16):2604-2622.

PMID: 38943248 PMC: 11365225. DOI: 10.1016/j.bpj.2024.06.027.