Don't Mess with the Matrix

Overview

Journal Nat Genet

Specialty Genetics

Date 2001 Jun 30

PMID 11431682

Citations 14

Authors

T H Vu

Affiliations

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Abstract

Extracellular matrix (ECM) remodeling is critical to morphogenesis and homeostasis. The identification of inactivating mutations in a gene encoding one of its modifying enzymes, matrix metalloproteinase 2 (MMP-2), in people with a hereditary disorder in which the bones disintegrate, represents the first genetic evidence that the proteolysis of the ECM mediates human growth and development. It also underscores the need for an intricate balance between breakdown and deposition of the ECM.

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