Granulatimide and 6-bromogranulatimide, Minor Alkaloids of the Brazilian Ascidian Didemnum Granulatum
Overview
Affiliations
Reinvestigation of the extract of the ascidian Didemnum granulatum collected on the Brazilian coastline led to the isolation of two minor compounds, granulatimide (2) and 6-bromogranulatimide (3), which have been identified by analysis of their spectroscopic data. The isolation of 2 and 3 from D. granulatum corroborates previous assumptions about the occurrence of granulatimide as a natural product.
Naturally Occurring Organohalogen Compounds-A Comprehensive Review.
Gribble G Prog Chem Org Nat Prod. 2023; 121:1-546.
PMID: 37488466 DOI: 10.1007/978-3-031-26629-4_1.
Youssef D, Almagthali H, Shaala L, Schmidt E Mar Drugs. 2020; 18(6).
PMID: 32545321 PMC: 7344992. DOI: 10.3390/md18060307.
Palanisamy S, Rajendran N, Marino A Nat Prod Bioprospect. 2017; 7(1):1-111.
PMID: 28097641 PMC: 5315671. DOI: 10.1007/s13659-016-0115-5.
Marine pyrrolocarbazoles and analogues: synthesis and kinase inhibition.
Deslandes S, Chassaing S, Delfourne E Mar Drugs. 2010; 7(4):754-86.
PMID: 20098609 PMC: 2810226. DOI: 10.3390/md7040754.
Divergent pathways in the biosynthesis of bisindole natural products.
Ryan K, Drennan C Chem Biol. 2009; 16(4):351-64.
PMID: 19389622 PMC: 2711870. DOI: 10.1016/j.chembiol.2009.01.017.