A Case of Malignant Proliferating Trichilemmoma of the Scalp with Multiple Metastases

Overview

Journal Korean J Intern Med

Specialty General Medicine

Date 2001 Jun 22

PMID 11417304

Citations 6

Authors

S B Bae

K K Lee

J S Kim

J H Lee

N S Lee

G T Lee

S K Park

J H Won

S H Baick

D S Hong

D W Lee

H S Park

Affiliations

Soon will be listed here.

Abstract

We report a case of malignant proliferating trichilemmal tumor showing multiple distant metastases. The patient demonstrated a round mass in the right occipital area for 12 months and the lesion grew rapidly to assume 8 x 6.5 x 4 cm in diameter, with areas of superficial erosion and crusting within the recent 3 months. The entire lesion was removed with a wide surgical excision. It recurred on the neck area 4 months after excision and the lesion was removed with surgical resection again. There was evidence of multiple metastases on CNS and mediastinal lymph nodes after 6 months. The patient was treated with cisplatin and etoposide combination chemotherapy and a partial response was achieved.

Citing Articles

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Scalp malignant trichilemmal tumour with bony erosion: a new clinical entity.

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References

Saida T, Oohara K, Hori Y, Tsuchiya S . Development of a malignant proliferating trichilemmal cyst in a patient with multiple trichilemmal cysts. Dermatologica. 1983; 166(4):203-8. DOI: 10.1159/000249868. View

HEADINGTON J . Tumors of the hair follicle. A review. Am J Pathol. 1976; 85(2):479-514. PMC: 2032578. View

MEHREGAN A . Hair follicle tumors of the skin. J Cutan Pathol. 1985; 12(3-4):189-95. DOI: 10.1111/j.1600-0560.1985.tb01621.x. View

Brownstein M, Arluk D . Proliferating trichilemmal cyst: a simulant of squamous cell carcinoma. Cancer. 1981; 48(5):1207-14. DOI: 10.1002/1097-0142(19810901)48:5<1207::aid-cncr2820480526>3.0.co;2-1. View

Park B, Yang S, Cho K . Malignant proliferating trichilemmal tumor showing distant metastases. Am J Dermatopathol. 1997; 19(5):536-9. DOI: 10.1097/00000372-199710000-00109. View

Casas J, Woscoff A . Giant pilar tumor of the scalp. Arch Dermatol. 1980; 116(12):1395. View

Laing V, Knipe R, Flowers F, Stoer C . Proliferating trichilemmal tumor: report of a case and review of the literature. J Dermatol Surg Oncol. 1991; 17(3):295-8. DOI: 10.1111/j.1524-4725.1991.tb03646.x. View

Weiss J, Heine M, Grimmel M, JUNG E . Malignant proliferating trichilemmal cyst. J Am Acad Dermatol. 1995; 32(5 Pt 2):870-3. DOI: 10.1016/0190-9622(95)91550-8. View

Amaral A, Nascimento A, Goellner J . Proliferating pilar (trichilemmal) cyst. Report of two cases, one with carcinomatous transformation and one with distant metastases. Arch Pathol Lab Med. 1984; 108(10):808-10. View

10.

Leppard B, Sanderson K . The natural history of trichilemmal cysts. Br J Dermatol. 1976; 94(4):379-90. DOI: 10.1111/j.1365-2133.1976.tb06115.x. View

11.

Poiares Baptista A, Garcia e Silva L, Born M . Proliferating trichilemmal cyst. J Cutan Pathol. 1983; 10(3):178-87. DOI: 10.1111/j.1600-0560.1983.tb00324.x. View

12.

MEHREGAN A, Lee K . Malignant proliferating trichilemmal tumors--report of three cases. J Dermatol Surg Oncol. 1987; 13(12):1339-42. DOI: 10.1111/j.1524-4725.1987.tb03579.x. View

13.

Holmes E . Tumors of lower hair sheath. Common histogenesis of certain so-called "sebaceous cysts," acanthomas and "sebaceous carcinomas". Cancer. 1968; 21(2):234-48. DOI: 10.1002/1097-0142(196802)21:2<234::aid-cncr2820210211>3.0.co;2-j. View