Protection from Superoxide Damage Associated with an Increased Level of the YggX Protein in Salmonella Enterica

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2001 Jun 21

PMID 11416172

Citations 23

Authors

J Gralnick

D Downs

Affiliations

Soon will be listed here.

Abstract

The deleterious effect of superoxide radicals on cell growth and survival is predominantly caused by rapid oxidation of labile [Fe-S] clusters in proteins. Oxidation of these clusters releases Fe(II) ions, which participate in Fenton chemistry that damages DNA. Here it is shown that elevated levels of the YggX protein increase the resistance of Salmonella enterica to superoxide stress, reverse enzymatic defects attributed to oxidized [Fe-S] clusters, and decrease the spontaneous mutation frequency. The data are consistent with a model in which YggX protects protein [Fe-S] clusters from oxidation.

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