Histidine Kinases and Response Regulator Proteins in Two-component Signaling Systems

Overview

Journal Trends Biochem Sci

Specialty Biochemistry

Date 2001 Jun 19

PMID 11406410

Citations 408

Authors

A H West

A M Stock

Affiliations

Soon will be listed here.

Abstract

Phosphotransfer-mediated signaling pathways allow cells to sense and respond to environmental stimuli. Autophosphorylating histidine protein kinases provide phosphoryl groups for response regulator proteins which, in turn, function as molecular switches that control diverse effector activities. Structural studies of proteins involved in two-component signaling systems have revealed a modular architecture with versatile conserved domains that are readily adapted to the specific needs of individual systems.

Citing Articles

CRISPR-mediated mutation of cytokinin signaling genes (SlHP2 and SlHP3) in tomato: Morphological, physiological, and molecular characterization.

Aydin A, Yerlikaya B, Yerlikaya S, Yilmaz N, Kavas M Plant Genome. 2025; 18(1):e20542.

PMID: 39779650 PMC: 11711121. DOI: 10.1002/tpg2.20542.

Genetics of conditional extended mycelial cell viability of in deep starvation phase implicates the involvement of (p)ppGpp, , and a histidine kinase .

Chatupale V, Pohnerkar J Front Microbiol. 2024; 15:1495007.

PMID: 39611085 PMC: 11604128. DOI: 10.3389/fmicb.2024.1495007.

Variations in kinase and effector signaling logic in a bacterial two component signaling network.

Swingle D, Epstein L, Aymon R, Isiorho E, Abzalimov R, Favaro D bioRxiv. 2024; .

PMID: 39574756 PMC: 11580852. DOI: 10.1101/2024.11.04.621962.

Diversification of molecular pattern recognition in bacterial NLR-like proteins.

Bechon N, Tal N, Stokar-Avihail A, Savidor A, Kupervaser M, Melamed S Nat Commun. 2024; 15(1):9860.

PMID: 39543107 PMC: 11564622. DOI: 10.1038/s41467-024-54214-0.

Key roles of two-component systems in intestinal signal sensing and virulence regulation in enterohemorrhagic Escherichia coli.

Sun H, Huang D, Pang Y, Chen J, Kang C, Zhao M FEMS Microbiol Rev. 2024; 48(6).

PMID: 39537200 PMC: 11644481. DOI: 10.1093/femsre/fuae028.