Evidence for a Correlation Between Antibody-dependent Cellular Cytotoxicity-mediating Anti-HIV-1 Antibodies and Prognostic Predictors of HIV Infection

Overview

Journal J Clin Immunol

Publisher Springer

Specialty Allergy & Immunology

Date 2001 Jun 14

PMID 11403230

Citations 71

Authors

R Ahmad

S T Sindhu

E Toma

R Morisset

J Vincelette

J Menezes

A Ahmad

Affiliations

Soon will be listed here.

Abstract

Using our gp120/41-expressing, NK cell activity-resistant CEM.NKR cell clones as targets in HIV-1-specific antibody-dependent cellular cytotoxicity (ADCC) assays, we demonstrate here that the serum titers of anti-HIV-1 ADCC antibodies bear a significant (P < 0.05) positive correlation with the peripheral blood CD4+ T cell counts and a negative one with the number of copies of HIV-1 RNA in the plasma of HIV-infected individuals. These findings underscore the importance of these antibodies as a protective immune parameter in these infections.

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