Neutrophil Diapedesis: Paracellular or Transcellular?

Overview

Journal News Physiol Sci

Specialty Physiology

Date 2001 Jun 8

PMID 11390940

Citations 13

Authors

P R Kvietys

M Sandig

Affiliations

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Abstract

To reach an inflammatory site in the interstitium, circulating neutrophils (PMN) must first traverse the endothelial barrier. Whether PMN emigrate between endothelial cells (paracellular pathway) or through the endothelial cells proper (transcellular pathway) is controversial. Herein, we present anatomic, functional, and teleological arguments that support both points of view. An attempt is also made to reconcile this apparent controversy.

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