Cation-Chloride Cotransporters in Neuronal Communication

Overview

Journal News Physiol Sci

Specialty Physiology

Date 2001 Jun 8

PMID 11390932

Citations 102

Authors

E Delpire

Affiliations

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Abstract

Two isoforms of the cation-Cl(-) cotransporter family are expressed in neurons and modulate neurotransmission. NKCC1, a Na(+)-K(+)-2Cl(-) cotransporter, by raising internal Cl(-), is responsible for excitatory GABAergic activity in immature brain and in adult sensory neurons. KCC2, a neuronal-specific isoform of the K(+)-Cl(-) cotransporter, by lowering internal Cl(-), is critical for inhibitory GABA responses in mature central nervous system neurons.

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Serine 937 phosphorylation enhances KCC2 activity and strengthens synaptic inhibition.

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NKCC1 and KCC2: Structural insights into phospho-regulation.

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