A Functional Magnetic Resonance Imaging Study of Auditory Mismatch in Schizophrenia

Overview

Journal Am J Psychiatry

Specialty Psychiatry

Date 2001 Jun 1

PMID 11384903

Citations 37

Authors

C G Wible

M Kubicki

S S Yoo

D F Kacher

D F Salisbury

M C Anderson

M E Shenton

Y Hirayasu

R Kikinis

F A Jolesz

R W McCarley

Affiliations

Soon will be listed here.

Abstract

Objective: Previous research has noted functional and structural temporal lobe abnormalities in schizophrenia that relate to symptoms such as auditory hallucinations and thought disorder. The goal of the study was to determine whether the functional abnormalities are present in schizophrenia at early stages of auditory processing.

Method: Functional magnetic resonance imaging activity was examined during the presentation of the mismatch stimuli, which are deviant tones embedded in a series of standard tones. The mismatch stimuli are used to elicit the mismatch negativity, an early auditory event-related potential. Ten patients with schizophrenia and 10 comparison subjects were presented the mismatch stimuli condition and a control condition in which only one tone was presented repeatedly.

Results: The superior temporal gyrus showed the most prevalent and consistent activation. The superior temporal gyrus showed less activation in the schizophrenic subjects than in the comparison subjects only during the mismatch stimuli condition.

Conclusions: This result is consistent with those of mismatch negativity event-related potential studies and suggests that early auditory processing is abnormal in chronic schizophrenia.

Citing Articles

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References

Kwon J, McCarley R, Hirayasu Y, Anderson J, Fischer I, Kikinis R . Left planum temporale volume reduction in schizophrenia. Arch Gen Psychiatry. 1999; 56(2):142-8. DOI: 10.1001/archpsyc.56.2.142. View

Stevens A, Goldman-Rakic P, Gore J, Fulbright R, Wexler B . Cortical dysfunction in schizophrenia during auditory word and tone working memory demonstrated by functional magnetic resonance imaging. Arch Gen Psychiatry. 1998; 55(12):1097-103. DOI: 10.1001/archpsyc.55.12.1097. View

Shelley A, Ward P, Catts S, Michie P, Andrews S, McConaghy N . Mismatch negativity: an index of a preattentive processing deficit in schizophrenia. Biol Psychiatry. 1991; 30(10):1059-62. DOI: 10.1016/0006-3223(91)90126-7. View

Tiitinen H, Alho K, Huotilainen M, Ilmoniemi R, Simola J, Naatanen R . Tonotopic auditory cortex and the magnetoencephalographic (MEG) equivalent of the mismatch negativity. Psychophysiology. 1993; 30(5):537-40. DOI: 10.1111/j.1469-8986.1993.tb02078.x. View

Naatanen R, Gaillard A, Mantysalo S . Early selective-attention effect on evoked potential reinterpreted. Acta Psychol (Amst). 1978; 42(4):313-29. DOI: 10.1016/0001-6918(78)90006-9. View

Kanwisher N, McDermott J, Chun M . The fusiform face area: a module in human extrastriate cortex specialized for face perception. J Neurosci. 1997; 17(11):4302-11. PMC: 6573547. View

Woodruff P, Wright I, Bullmore E, Brammer M, Howard R, Williams S . Auditory hallucinations and the temporal cortical response to speech in schizophrenia: a functional magnetic resonance imaging study. Am J Psychiatry. 1997; 154(12):1676-82. DOI: 10.1176/ajp.154.12.1676. View

Hirayasu Y, Potts G, ODonnell B, Kwon J, ARAKAKI H, Akdag S . Auditory mismatch negativity in schizophrenia: topographic evaluation with a high-density recording montage. Am J Psychiatry. 1998; 155(9):1281-4. DOI: 10.1176/ajp.155.9.1281. View

Wexler B, Stevens A, Bowers A, Sernyak M, Goldman-Rakic P . Word and tone working memory deficits in schizophrenia. Arch Gen Psychiatry. 1998; 55(12):1093-6. DOI: 10.1001/archpsyc.55.12.1093. View

10.

Kropotov J, Naatnen R, Sevostianov A, Alho K, Reinikainen K, Kropotova O . Mismatch negativity to auditory stimulus change recorded directly from the human temporal cortex. Psychophysiology. 1995; 32(4):418-22. DOI: 10.1111/j.1469-8986.1995.tb01226.x. View

11.

Opitz B, Mecklinger A, Friederici A, von Cramon D . The functional neuroanatomy of novelty processing: integrating ERP and fMRI results. Cereb Cortex. 1999; 9(4):379-91. DOI: 10.1093/cercor/9.4.379. View

12.

Wible C, Shenton M, Fischer I, Allard J, Kikinis R, Jolesz F . Parcellation of the human prefrontal cortex using MRI. Psychiatry Res. 1998; 76(1):29-40. DOI: 10.1016/s0925-4927(97)00060-7. View

13.

Buckner R, Koutstaal W, Schacter D, Wagner A, Rosen B . Functional-anatomic study of episodic retrieval using fMRI. I. Retrieval effort versus retrieval success. Neuroimage. 1998; 7(3):151-62. DOI: 10.1006/nimg.1998.0327. View

14.

Oades R, Zerbin D, Eggers C . Negative difference (Nd), an ERP marker of stimulus relevance: different lateral asymmetries for paranoid and nonparanoid schizophrenics. Pharmacopsychiatry. 1994; 27(2):65-7. DOI: 10.1055/s-2007-1014279. View

15.

Renshaw P, Levin J, Kaufman M, Ross M, Lewis R, Harris G . Dynamic susceptibility contrast magnetic resonance imaging in neuropsychiatry: present utility and future promise. Eur Radiol. 1997; 7 Suppl 5:216-21. DOI: 10.1007/pl00006895. View

16.

Opitz B, Mecklinger A, von Cramon D, Kruggel F . Combining electrophysiological and hemodynamic measures of the auditory oddball. Psychophysiology. 1999; 36(1):142-7. DOI: 10.1017/s0048577299980848. View

17.

Javitt D, Doneshka P, Zylberman I, Ritter W, Vaughan Jr H . Impairment of early cortical processing in schizophrenia: an event-related potential confirmation study. Biol Psychiatry. 1993; 33(7):513-9. DOI: 10.1016/0006-3223(93)90005-x. View

18.

Yurgelun-Todd D, Waternaux C, Cohen B, Gruber S, English C, Renshaw P . Functional magnetic resonance imaging of schizophrenic patients and comparison subjects during word production. Am J Psychiatry. 1996; 153(2):200-5. DOI: 10.1176/ajp.153.2.200. View

19.

Csepe V, Karmos G, Molnar M . Evoked potential correlates of stimulus deviance during wakefulness and sleep in cat--animal model of mismatch negativity. Electroencephalogr Clin Neurophysiol. 1987; 66(6):571-8. DOI: 10.1016/0013-4694(87)90103-9. View

20.

Umbricht D, Javitt D, Novak G, Bates J, Pollack S, Lieberman J . Effects of clozapine on auditory event-related potentials in schizophrenia. Biol Psychiatry. 1998; 44(8):716-25. DOI: 10.1016/s0006-3223(97)00524-6. View