Goat-associated Q Fever: a New Disease in Newfoundland

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 2001 Jun 1

PMID 11384518

Citations 35

Authors

T F Hatchette

R C HUDSON

W F Schlech

N A Campbell

J E Hatchette

S Ratnam

D Raoult

C Donovan

T J Marrie

Affiliations

Soon will be listed here.

Abstract

In the spring of 1999 in rural Newfoundland, abortions in goats were associated with illness in goat workers. An epidemiologic investigation and a serologic survey were conducted in April 1999 to determine the number of infections, nature of illness, and risk factors for infection. Thirty-seven percent of the outbreak cohort had antibody titers to phase II Coxiella burnetii antigen >1:64, suggesting recent infection. The predominant clinical manifestation of Q fever was an acute febrile illness. Independent risk factors for infection included contact with goat placenta, smoking tobacco, and eating cheese made from pasteurized goat milk. This outbreak raises questions about management of such outbreaks, interprovincial sale and movement of domestic ungulates, and the need for discussion between public health practitioners and the dairy industry on control of this highly infectious organism.

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References

Benson W, Brock D, Mather J . SEROLOGIC ANALYSIS OF A PENITENTIARY GROUP USING RAW MILK FROM A Q FEVER INFECTED HERD. Public Health Rep (1896). 1963; 78:707-10. PMC: 1915294. View

KAPLAN M, BERTAGNA P . The geographical distribution of Q fever. Bull World Health Organ. 1955; 13(5):829-60. PMC: 2538086. View

Wisniewski H, KRUMBIEGEL E . Q fever in the Milwaukee area. I. Q fever in Milwaukee area cattle. Arch Environ Health. 1970; 21(1):58-62. DOI: 10.1080/00039896.1970.10667192. View

KRUMBIEGEL E, Wisniewski H . Q fever in the Milwaukee area. II. Consumption of infected raw milk by human volunteers. Arch Environ Health. 1970; 21(1):63-5. DOI: 10.1080/00039896.1970.10667193. View

DERRICK E . The course of infection with Coxiella burneti. Med J Aust. 1973; 1(21):1051-7. View

Hart R . The epidemiology of Q fever. Postgrad Med J. 1973; 49(574):535-8. PMC: 2495609. DOI: 10.1136/pgmj.49.574.535. View

Biberstein E, Behymer D, Bushnell R, Crenshaw G, Riemann H, Franti C . A survey of Q fever (Coxiella burnetii) in California dairy cows. Am J Vet Res. 1974; 35(12):1577-82. View

Spicer A, CROWTHER R, Vella E, Bengtsson E, Miles R, Pitzolis G . Q fever and animal abortion in Cyprus. Trans R Soc Trop Med Hyg. 1977; 71(1):16-20. DOI: 10.1016/0035-9203(77)90198-5. View

Daniele R, Dauber J, Altose M, Rowlands Jr D, Gorenberg D . Lymphocyte studies in asymptomatic cigarette smokers. A comparison between lung and peripheral blood. Am Rev Respir Dis. 1977; 116(6):997-1005. DOI: 10.1164/arrd.1977.116.6.997. View

10.

ORMSBEE R, Peacock M, GERLOFF R, TALLENT G, WIKE D . Limits of rickettsial infectivity. Infect Immun. 1978; 19(1):239-45. PMC: 414073. DOI: 10.1128/iai.19.1.239-245.1978. View

11.

Peacock M, PHILIP R, Williams J, FAULKNER R . Serological evaluation of O fever in humans: enhanced phase I titers of immunoglobulins G and A are diagnostic for Q fever endocarditis. Infect Immun. 1983; 41(3):1089-98. PMC: 264612. DOI: 10.1128/iai.41.3.1089-1098.1983. View

12.

Simor A, Brunton J, Salit I, Vellend H, Ford-Jones L, SPENCE L . Q fever: hazard from sheep used in research. Can Med Assoc J. 1984; 130(8):1013-6. PMC: 1876061. View

13.

Marrie T, van Buren J, FAULKNER R, Haldane E, Williams J, Kwan C . Seroepidemiology of Q fever in Nova Scotia and Prince Edward Island. Can J Microbiol. 1984; 30(1):129-34. DOI: 10.1139/m84-021. View

14.

Marrie T, van Buren J, Fraser J, Haldane E, FAULKNER R, Williams J . Seroepidemiology of Q fever among domestic animals in Nova Scotia. Am J Public Health. 1985; 75(7):763-6. PMC: 1646304. DOI: 10.2105/ajph.75.7.763. View

15.

Dupuis G, Petite J, Peter O, Vouilloz M . An important outbreak of human Q fever in a Swiss Alpine valley. Int J Epidemiol. 1987; 16(2):282-7. DOI: 10.1093/ije/16.2.282. View

16.

Marrie T, Macdonald A, DURANT H, Yates L, McCORMICK L . An outbreak of Q fever probably due to contact with a parturient cat. Chest. 1988; 93(1):98-103. DOI: 10.1378/chest.93.1.98. View

17.

Lang G . Serosurvey of Coxiella burnetii infection in dairy goat herds in Ontario. A comparison of two methods of enzyme-linked immunosorbent assay. Can J Vet Res. 1988; 52(1):37-41. PMC: 1255397. View

18.

Lang G . Serosurvey on the occurrence of Coxiella burnetii in Ontario cattle. Can J Public Health. 1988; 79(1):56-9. View

19.

Marrie T, DURANT H, Williams J, Mintz E, Waag D . Exposure to parturient cats: a risk factor for acquisition of Q fever in Maritime Canada. J Infect Dis. 1988; 158(1):101-8. DOI: 10.1093/infdis/158.1.101. View

20.

Marrie T . Seroepidemiology of Q fever in New Brunswick and Manitoba. Can J Microbiol. 1988; 34(9):1043-5. DOI: 10.1139/m88-183. View