Seasonal Variation in Host Susceptibility and Cycles of Certain Infectious Diseases

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 2001 Jun 1

PMID 11384511

Citations 219

Authors

S F Dowell

Affiliations

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Abstract

Seasonal cycles of infectious diseases have been variously attributed to changes in atmospheric conditions, the prevalence or virulence of the pathogen, or the behavior of the host. Some observations about seasonality are difficult to reconcile with these explanations. These include the simultaneous appearance of outbreaks across widespread geographic regions of the same latitude; the detection of pathogens in the off-season without epidemic spread; and the consistency of seasonal changes, despite wide variations in weather and human behavior. In contrast, an increase in susceptibility of the host population, perhaps linked to the annual light/dark cycle and mediated by the pattern of melatonin secretion, might account for many heretofore unexplained features of infectious disease seasonality. Ample evidence indicates that photoperiod-driven physiologic changes are typical in mammalian species, including some in humans. If such physiologic changes underlie human resistance to infectious diseases for large portions of the year and the changes can be identified and modified, the therapeutic and preventive implications may be considerable.

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References

SUNG R, Murray H, Chan R, Davies D, French G . Seasonal patterns of respiratory syncytial virus infection in Hong Kong: a preliminary report. J Infect Dis. 1987; 156(3):527-8. DOI: 10.1093/infdis/156.3.527. View

Hope-Simpson R, GOLUBEV D . A new concept of the epidemic process of influenza A virus. Epidemiol Infect. 1987; 99(1):5-54. PMC: 2249185. DOI: 10.1017/s0950268800066851. View

Boctor F, Charmy R, Cooper E . Seasonal differences in the rhythmicity of human male and female lymphocyte blastogenic responses. Immunol Invest. 1989; 18(6):775-84. DOI: 10.3109/08820138909030598. View

Carlson L, Zimmermann A, Lynch G . Geographic differences for delay of sexual maturation in Peromyscus leucopus: effects of photoperiod, pinealectomy, and melatonin. Biol Reprod. 1989; 41(6):1004-13. DOI: 10.1095/biolreprod41.6.1004. View

Cook S, Glass R, LeBaron C, Ho M . Global seasonality of rotavirus infections. Bull World Health Organ. 1990; 68(2):171-7. PMC: 2393128. View

Rojansky N, Brzezinski A, Schenker J . Seasonality in human reproduction: an update. Hum Reprod. 1992; 7(6):735-45. DOI: 10.1093/oxfordjournals.humrep.a137729. View

Wehr T, Moul D, Barbato G, Giesen H, Seidel J, Barker C . Conservation of photoperiod-responsive mechanisms in humans. Am J Physiol. 1993; 265(4 Pt 2):R846-57. DOI: 10.1152/ajpregu.1993.265.4.R846. View

Maes M, Stevens W, Scharpe S, Bosmans E, De Meyer F, DHondt P . Seasonal variation in peripheral blood leukocyte subsets and in serum interleukin-6, and soluble interleukin-2 and -6 receptor concentrations in normal volunteers. Experientia. 1994; 50(9):821-9. DOI: 10.1007/BF01956463. View

Kohn M, Farley T, Sundin D, Tapia R, McFarland L, Arden N . Three summertime outbreaks of influenza type A. J Infect Dis. 1995; 172(1):246-9. DOI: 10.1093/infdis/172.1.246. View

10.

Riedo F, Plikaytis B, Broome C . Epidemiology and prevention of meningococcal disease. Pediatr Infect Dis J. 1995; 14(8):643-57. DOI: 10.1097/00006454-199508000-00001. View

11.

Calvo J, Pozo D, Guerrero J . Immunomodulatory role of melatonin: specific binding sites in human and rodent lymphoid cells. J Pineal Res. 1995; 18(3):119-26. DOI: 10.1111/j.1600-079x.1995.tb00149.x. View

12.

. Update: influenza activity--United States and Worldwide, 1995-96 season, and composition of the 1996-97 influenza vaccine. MMWR Morb Mortal Wkly Rep. 1996; 45(16):326-9. View

13.

Kim P, Musher D, Glezen W, Rodriguez-Barradas M, Nahm W, Wright C . Association of invasive pneumococcal disease with season, atmospheric conditions, air pollution, and the isolation of respiratory viruses. Clin Infect Dis. 1996; 22(1):100-6. DOI: 10.1093/clinids/22.1.100. View

14.

Loscher W, Fiedler M . The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. VI. Seasonal influences on maximal electroshock and pentylenetetrazol seizure thresholds. Epilepsy Res. 1996; 25(1):3-10. DOI: 10.1016/0920-1211(96)00022-8. View

15.

Herndon J, BEIN M, Nordmeyer D, Turner J . Seasonal testicular function in male rhesus monkeys. Horm Behav. 1996; 30(3):266-71. DOI: 10.1006/hbeh.1996.0032. View

16.

Deming M, Linkins R, Jaiteh K, Hull H . The clinical efficacy of trivalent oral polio vaccine in The Gambia by season of vaccine administration. J Infect Dis. 1997; 175 Suppl 1:S254-7. DOI: 10.1093/infdis/175.supplement_1.s254. View

17.

Torok T, Kilgore P, Clarke M, Holman R, Bresee J, Glass R . Visualizing geographic and temporal trends in rotavirus activity in the United States, 1991 to 1996. National Respiratory and Enteric Virus Surveillance System Collaborating Laboratories. Pediatr Infect Dis J. 1997; 16(10):941-6. DOI: 10.1097/00006454-199710000-00007. View

18.

Cox N, Fukuda K . Influenza. Infect Dis Clin North Am. 1998; 12(1):27-38. DOI: 10.1016/s0891-5520(05)70406-2. View

19.

Demas G, Nelson R . Exogenous melatonin enhances cell-mediated, but not humoral, immune function in adult male deer mice (Peromyscus maniculatus). J Biol Rhythms. 1998; 13(3):245-52. DOI: 10.1177/074873098129000084. View

20.

Chew F, Doraisingham S, Ling A, Kumarasinghe G, Lee B . Seasonal trends of viral respiratory tract infections in the tropics. Epidemiol Infect. 1998; 121(1):121-8. PMC: 2809482. DOI: 10.1017/s0950268898008905. View