Coumarins Isolated from Angelica Gigas Inhibit Acetylcholinesterase: Structure-activity Relationships

Overview

Journal J Nat Prod

Date 2001 May 26

PMID 11374978

Citations 25

Authors

S Y Kang

K Y Lee

S H Sung

M J Park

Y C Kim

Affiliations

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Abstract

Acetylcholinesterase (AChE) inhibitory activity-guided fractionation of Angelica gigas led to isolation and identification of a new coumarin, peucedanone (12), and isolation of 11 known coumarins. Among them, decursinol (1) represented the highest inhibitory activity toward AChE in vitro. The correlation of the inhibitory activities of the coumarins toward AChE with their chemical structures was studied.

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