Carnitine Palmitoyl Transferase I and the Control of Myocardial Beta-oxidation Flux

Overview

Journal Biochem Soc Trans

Specialty Biochemistry

Date 2001 May 18

PMID 11356163

Citations 8

Authors

S Eaton

K Fukumoto

N Paladio Duran

A Pierro

L Spitz

P A Quant

K Bartlett

Affiliations

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Abstract

Carnitine palmitoyltransferase I is assumed to be rate limiting for beta-oxidation in all tissues. However, the concentration of malonyl-CoA in heart and muscle is high and is enough to completely inhibit beta-oxidation if this assumption is correct. In this review, we consider whether: (i) there is a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity; (ii) the measured malonyl-CoA concentration in the heart is physiologically meaningful; and (iii) carnitine palmitoyltransferase I is rate-limiting for beta-oxidation in the heart.

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