Neurotrophins and Synaptic Plasticity in the Mammalian Spinal Cord

Overview

Journal J Physiol

Specialty Physiology

Date 2001 May 15

PMID 11351017

Citations 37

Authors

L M Mendell

J B Munson

V L Arvanian

Affiliations

Soon will be listed here.

Abstract

The pathway mediating the monosynaptic stretch reflex has served as an important model system for studies of plasticity in the spinal cord. Its usefulness is extended by evidence that neurotrophins, particularly neurotrophin-3 (NT-3), which has been shown to promote spinal axon elongation, can modulate the efficacy of the muscle spindle-motoneurone connection both after peripheral nerve injury and during development. The findings summarized here emphasize the potential for neurotrophins to modify function of both damaged and undamaged neurones. It is important to recognize that these effects may be functionally detrimental as well as beneficial.

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References

Oakley R, Garner A, Large T, Frank E . Muscle sensory neurons require neurotrophin-3 from peripheral tissues during the period of normal cell death. Development. 1995; 121(5):1341-50. DOI: 10.1242/dev.121.5.1341. View

Collins 3rd W, Mendell L, Munson J . On the specificity of sensory reinnervation of cat skeletal muscle. J Physiol. 1986; 375:587-609. PMC: 1182777. DOI: 10.1113/jphysiol.1986.sp016135. View

Schnell L, Schneider R, Kolbeck R, Barde Y, Schwab M . Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion. Nature. 1994; 367(6459):170-3. DOI: 10.1038/367170a0. View

Farhadi H, Mowla S, Petrecca K, Morris S, Seidah N, Murphy R . Neurotrophin-3 sorts to the constitutive secretory pathway of hippocampal neurons and is diverted to the regulated secretory pathway by coexpression with brain-derived neurotrophic factor. J Neurosci. 2000; 20(11):4059-68. PMC: 6772649. View

Yamamoto H, TAN S, Brickey D, Soderling T . Phosphorylation and regulation of glutamate receptors by calcium/calmodulin-dependent protein kinase II. Nature. 1993; 362(6421):640-2. DOI: 10.1038/362640a0. View

Carmignoto G, Vicini S . Activity-dependent decrease in NMDA receptor responses during development of the visual cortex. Science. 1992; 258(5084):1007-11. DOI: 10.1126/science.1279803. View

Kucera J, Fan G, Jaenisch R, Linnarsson S, Ernfors P . Dependence of developing group Ia afferents on neurotrophin-3. J Comp Neurol. 1995; 363(2):307-20. DOI: 10.1002/cne.903630211. View

Mendell L, Johnson R, Munson J . Neurotrophin modulation of the monosynaptic reflex after peripheral nerve transection. J Neurosci. 1999; 19(8):3162-70. PMC: 6782282. View

Seebach B, Arvanov V, Mendell L . Effects of BDNF and NT-3 on development of Ia/motoneuron functional connectivity in neonatal rats. J Neurophysiol. 1999; 81(5):2398-405. DOI: 10.1152/jn.1999.81.5.2398. View

10.

Munson J, Johnson R, Mendell L . NT-3 increases amplitude of EPSPs produced by axotomized group Ia afferents. J Neurophysiol. 1997; 77(4):2209-12. DOI: 10.1152/jn.1997.77.4.2209. View

11.

Tonra J, Mendell L . Rabbit IgG distribution in skin, spinal cord and DRG following systemic injection in rat. J Neuroimmunol. 1997; 80(1-2):97-105. DOI: 10.1016/s0165-5728(97)00140-9. View

12.

Thoenen H . The changing scene of neurotrophic factors. Trends Neurosci. 1991; 14(5):165-70. DOI: 10.1016/0166-2236(91)90097-e. View

13.

Snider W . Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. Cell. 1994; 77(5):627-38. DOI: 10.1016/0092-8674(94)90048-5. View

14.

Gonzalez M, Collins 3rd W . Modulation of motoneuron excitability by brain-derived neurotrophic factor. J Neurophysiol. 1997; 77(1):502-6. DOI: 10.1152/jn.1997.77.1.502. View

15.

Ramer M, Priestley J, McMahon S . Functional regeneration of sensory axons into the adult spinal cord. Nature. 2000; 403(6767):312-6. DOI: 10.1038/35002084. View

16.

Lozier A, Kendig J . Long-term potentiation in an isolated peripheral nerve-spinal cord preparation. J Neurophysiol. 1995; 74(3):1001-9. DOI: 10.1152/jn.1995.74.3.1001. View

17.

HESTRIN S . Developmental regulation of NMDA receptor-mediated synaptic currents at a central synapse. Nature. 1992; 357(6380):686-9. DOI: 10.1038/357686a0. View

18.

Munson J, Shelton D, McMahon S . Adult mammalian sensory and motor neurons: roles of endogenous neurotrophins and rescue by exogenous neurotrophins after axotomy. J Neurosci. 1997; 17(1):470-6. PMC: 6793713. View

19.

Pinco M, Lev-Tov A . Synaptic transmission between ventrolateral funiculus axons and lumbar motoneurons in the isolated spinal cord of the neonatal rat. J Neurophysiol. 1994; 72(5):2406-19. DOI: 10.1152/jn.1994.72.5.2406. View

20.

Schecterson L, Bothwell M . Novel roles for neurotrophins are suggested by BDNF and NT-3 mRNA expression in developing neurons. Neuron. 1992; 9(3):449-63. DOI: 10.1016/0896-6273(92)90183-e. View