Brain Protein Oxidation in Age-related Neurodegenerative Disorders That Are Associated with Aggregated Proteins

Overview

Journal Mech Ageing Dev

Specialty Geriatrics

Date 2001 May 12

PMID 11348660

Citations 102

Authors

D A Butterfield

J Kanski

Affiliations

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Abstract

Protein oxidation, one of a number of brain biomarkers of oxidative stress, is increased in several age-related neurodegenerative disorders or animal models thereof, including Alzheimer's disease, Huntington's disease, prion disorders, such as Creutzfeld-Jakob disease, and alpha-synuclein disorders, such as Parkinson's disease and frontotemporal dementia. Each of these neurodegenerative disorders is associated with aggregated proteins in brain. However, the relationship among protein oxidation, protein aggregation, and neurodegeneration remain unclear. The current rapid progress in elucidation of mechanisms of protein oxidation in neuronal loss should provide further insight into the importance of free radical oxidative stress in these neurodegenerative disorders.

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