Extreme Warfarin Sensitivity in Siblings Associated with Multiple Cytochrome P450 Polymorphisms

Overview

Journal Am J Hematol

Specialty Hematology

Date 2001 May 9

PMID 11343389

Citations 4

Authors

A R Tabrizi

S D McGRATH

M A Blinder

T G Buchman

B A Zehnbauer

B D Freeman

Affiliations

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Abstract

Warfarin use is complicated by an erratic dose response. Warfarin is metabolized by two distinct subfamilies of the cytochrome P450 (CYP) complex. We describe two siblings with extreme sensitivity to warfarin who share an unusual CYP genotype. These individuals illustrate both the importance of genetics in influencing the metabolism of warfarin as well as the potential utility of genetic testing as a guide to prescribing this medication.

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