AcrAB and Related Multidrug Efflux Pumps of Escherichia Coli

Overview

Journal J Mol Microbiol Biotechnol

Publisher Karger

Specialties Biotechnology
Microbiology
Molecular Biology

Date 2001 Apr 26

PMID 11321576

Citations 90

Authors

H Nikaido

H I Zgurskaya

Affiliations

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Abstract

The AcrAB system of Escherichia coli is a multidrug efflux system composed of an RND-type transporter AcrB and a periplasmic accessory protein AcrA, and pumps out a wide variety of lipophilic and amphiphilic inhibitors directly into the medium, presumably through the TolC outer membrane channel. AcrA, a highly elongated protein, is thought to bring the outer and inner membranes closer. It forms a trimer that interacts with a monomeric AcrB, which was shown by in vitro reconstitution to be a proton antiporter. Details of interaction between the

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