The Fas Signaling Connection Between Autoimmunity and Embryonic Lethality

Overview

Journal J Clin Immunol

Publisher Springer

Specialty Allergy & Immunology

Date 2001 Apr 26

PMID 11321232

Citations 1

Authors

H C Hsu

Y Matsuki

H G Zhang

T Zhou

J D Mountz

Affiliations

Soon will be listed here.

Abstract

The first gene to cause systemic autoimmune disease in mice was identified as the fas gene, which is mutated in lymphoproliferative (lpr) mice. These mice exhibited a defect in activation-inducted cell death of T cells and B cells in vivo, causing a failure of proper clearance of immune cells and defective down-modulation of an immune response. This led to the speculation that apoptosis defects may play a role in defective down-modulation of the hyperimmune response observed in human autoimmune diseases. More recently, scientists have generated different mouse lines with defects in Fas-apoptosis-associated molecules such as FADD and Apaf-1. These mice, however, died during embryonic development and did not develop autoimmune disease. These findings suggest that molecules associated with Fas apoptosis signaling can be important at the most limited levels for development of the immune system but also have more global apoptosis roles in other systems. We propose that the more global role of Fas-associated apoptosis molecules should be considered when evaluating their role in autoimmune disease.

Citing Articles

The Fas death signaling pathway connecting reactive oxygen species generation and FLICE inhibitory protein down-regulation.

Wang L, Azad N, Kongkaneramit L, Chen F, Lu Y, Jiang B J Immunol. 2008; 180(5):3072-80.

PMID: 18292530 PMC: 3833600. DOI: 10.4049/jimmunol.180.5.3072.

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