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A Randomised, Double Masked, Clinical Trial of High Dose Vitamin A and Vitamin E Supplementation After Photorefractive Keratectomy

Overview
Journal Br J Ophthalmol
Specialty Ophthalmology
Date 2001 Apr 24
PMID 11316710
Citations 11
Authors
M Vetrugno
A Maino
G Cardia
G M Quaranta
L Cardia
Affiliations
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Abstract

Aim: To evaluate the effect of a high dose vitamin A and E supplementation on corneal re-epithelialisation time, visual acuity and haze following photorefractive keratectomy (PRK).

Methods: Two groups of 20 patients who underwent myopic PRK were supplemented with either 25 000 IU retinol palmitate and 230 mg alpha tocopheryl nicotinate or a placebo. Clinical outcomes were evaluated up to 360 days.

Results: In the vitamin treated group, re-epithelialisation time was significantly faster (p = 0.029) and haze incidence was reduced (p = 0.035), especially for high myopic corrections (p = 0.043). This group also reported a significantly better uncorrected visual acuity (p = 0.043).

Conclusions: High dose vitamin A and E oral supplementation may accelerate re-epithelialisation time and may reduce corneal haze formation after PRK.

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No Evidence of an Association between Genetic Factors Affecting Response to Vitamin A Supplementation and Myopia: A Mendelian Randomization Study and Meta-Analysis.

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Transepithelial Photorefractive Keratectomy-Review.

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Management of Corneal Haze After Photorefractive Keratectomy.

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