Osmotic Forces and Gap Junctions in Spreading Depression: a Computational Model

Overview

Journal J Comput Neurosci

Specialties Biology
Neurology

Date 2001 Apr 24

PMID 11316343

Citations 21

Authors

B E Shapiro

Affiliations

Soon will be listed here.

Abstract

In a computational model of spreading depression (SD), ionic movement through a neuronal syncytium of cells connected by gap junctions is described electrodiffusively. Simulations predict that SD will not occur unless cells are allowed to expand in response to osmotic pressure gradients and K+ is allowed to move through gap junctions. SD waves of [K+]out approximately 25 to approximately 60 mM moving at approximately 2 to approximately 18 mm/min are predicted over the range of parametric values reported in gray matter, with extracellular space decreasing up to approximately 50%. Predicted waveform shape is qualitatively similar to laboratory reports. The delayed-rectifier, NMDA, BK, and Na+ currents are predicted to facilitate SD, while SK and A-type K+ currents and glial activity impede SD. These predictions are consonant with recent findings that gap junction poisons block SD and support the theories that cytosolic diffusion via gap junctions and osmotic forces are important mechanisms underlying SD.

Citing Articles

Mathematical Psychiatry: On Cortical Spreading Depression-A Review.

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Validating a Computational Framework for Ionic Electrodiffusion with Cortical Spreading Depression as a Case Study.

Ellingsrud A, Dukefoss D, Enger R, Halnes G, Pettersen K, Rognes M eNeuro. 2022; 9(2).

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The Critical Role of Spreading Depolarizations in Early Brain Injury: Consensus and Contention.

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Saetra M, Einevoll G, Halnes G PLoS Comput Biol. 2021; 17(7):e1008143.

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