Multiple Single-nucleotide Polymorphisms (SNPs) in the Japanese Population in Six Candidate Genes for Long QT Syndrome

Overview

Journal J Hum Genet

Specialty Genetics

Date 2001 Apr 20

PMID 11310586

Citations 6

Authors

H Iwasa

M Kurabayashi

R Nagai

Y Nakamura

T Tanaka

Affiliations

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Abstract

We report here 20 single-nucleotide polymorphisms (SNPs), including 15 novel ones, in six genes that are considered to be candidates for long QT syndrome (LQTS): 2 SNPs in KCNB1, 3 in KCND3, 3 in KCNJ11, 7 in ABCC9, 3 in ADRB1, and 2 in SLC18A2. We also examined their allelic frequencies in a Japanese sample population of LQTS-affected and nonaffected individuals. These data will be useful for genetic association studies designed to investigate acquired arrhythmias.

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