Quinolone Resistance in Neisseria Gonorrhoeae

Overview

Journal Curr Infect Dis Rep

Specialty Infectious Diseases

Date 2001 Apr 5

PMID 11286658

Citations 4

Authors

Janine R. Tompkins

Jonathan M Zenilman

Affiliations

Soon will be listed here.

Abstract

Single-dose oral quinolones have been recommended for gonorrhea treatment since 1989. The antimicrobial resistance surveillance system has detected several outbreaks of quinolone-resistant gonococcal infections (QRNG), and sporadic treatment failures have been reported from high-incidence areas such as southeast Asia. QRNG may result from mutations that cause structural-functional changes in DNA topoisomerase (the quinolone target enzyme) or by changes in antimicrobial transport into the bacteria. QRNG has occurred sporadically in the United States, predominantly in persons with contact to persons in southeast Asia, and has typically occurred as an epiphenomenon in persons who were treated with other regimens. Nevertheless, this entity warrants close monitoring. The emergence of QRNG is probably related to antimicrobial misuse and overuse, in particular long-term suppressive or subtherapeutic doses.

Citing Articles

Population dynamics of Neisseria gonorrhoeae in Shanghai, China: a comparative study.

Tazi L, Perez-Losada M, Gu W, Yang Y, Xue L, Crandall K BMC Infect Dis. 2010; 10:13.

PMID: 20092631 PMC: 2822776. DOI: 10.1186/1471-2334-10-13.

por Variable-region typing by DNA probe hybridization is broadly applicable to epidemiologic studies of Neisseria gonorrhoeae.

Bash M, Zhu P, Gulati S, McKnew D, Rice P, Lynn F J Clin Microbiol. 2005; 43(4):1522-30.

PMID: 15814961 PMC: 1081315. DOI: 10.1128/JCM.43.4.1522-1530.2005.

Sexually Transmitted Diseases in Travelers.

Hynes N Curr Infect Dis Rep. 2005; 7(2):132-137.

PMID: 15727741 DOI: 10.1007/s11908-005-0073-2.

Update on Quinolone Resistance in Neisseria gonorrhoeae.

Zenilman J Curr Infect Dis Rep. 2002; 4(2):144-147.

PMID: 11927047 DOI: 10.1007/s11908-002-0056-5.

References

Corkill J, Percival A, Lind M . Reduced uptake of ciprofloxacin in a resistant strain of Neisseria gonorrhoeae and transformation of resistance to other strains. J Antimicrob Chemother. 1991; 28(4):601-4. DOI: 10.1093/jac/28.4.601. View

Fox K, Knapp J, Holmes K, Hook 3rd E, Judson F, THOMPSON S . Antimicrobial resistance in Neisseria gonorrhoeae in the United States, 1988-1994: the emergence of decreased susceptibility to the fluoroquinolones. J Infect Dis. 1997; 175(6):1396-403. DOI: 10.1086/516472. View

Tanaka M, Nakayama H, Haraoka M, Nagafuji T, Saika T, Kobayashi I . Analysis of quinolone resistance mechanisms in a sparfloxacin-resistant clinical isolate of Neisseria gonorrhoeae. Sex Transm Dis. 1998; 25(9):489-93. DOI: 10.1097/00007435-199810000-00009. View

Kam K, Lo K, Lai C, Lee Y, Chan C . Ofloxacin susceptibilities of 5,667 Neisseria gonorrhoeae strains isolated in Hong Kong. Antimicrob Agents Chemother. 1993; 37(9):2007-8. PMC: 188111. DOI: 10.1128/AAC.37.9.2007. View

Deguchi T, Yasuda M, Nakano M, Ozeki S, Ezaki T, Saito I . Quinolone-resistant Neisseria gonorrhoeae: correlation of alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV with antimicrobial susceptibility profiles. Antimicrob Agents Chemother. 1996; 40(4):1020-3. PMC: 163251. DOI: 10.1128/AAC.40.4.1020. View

Wolfson J, Hooper D . Bacterial resistance to quinolones: mechanisms and clinical importance. Rev Infect Dis. 1989; 11 Suppl 5:S960-8. DOI: 10.1093/clinids/11.supplement_5.s960. View

Zenilman J . Gonococcal susceptibility to antimicrobials in Baltimore, 1988-1994. What was the impact of ciprofloxacin as first-line therapy for gonorrhea?. Sex Transm Dis. 1996; 23(3):213-8. DOI: 10.1097/00007435-199605000-00009. View

Moran J, Levine W . Drugs of choice for the treatment of uncomplicated gonococcal infections. Clin Infect Dis. 1995; 20 Suppl 1:S47-65. DOI: 10.1093/clinids/20.supplement_1.s47. View

Kam K, Lo K, Ho N, Cheung M . Rapid decline in penicillinase-producing Neisseria gonorrhoeae in Hong Kong associated with emerging 4-fluoroquinolone resistance. Genitourin Med. 1995; 71(3):141-4. PMC: 1195485. DOI: 10.1136/sti.71.3.141. View

10.

Wolfson J, Hooper D . The fluoroquinolones: structures, mechanisms of action and resistance, and spectra of activity in vitro. Antimicrob Agents Chemother. 1985; 28(4):581-6. PMC: 180310. DOI: 10.1128/AAC.28.4.581. View

11.

Richard P, Delangle M, Merrien D, Barille S, Reynaud A, Minozzi C . Fluoroquinolone use and fluoroquinolone resistance: is there an association?. Clin Infect Dis. 1994; 19(1):54-9. DOI: 10.1093/clinids/19.1.54. View

12.

Knapp J, Washington J, Doyle L, Neal S, Parekh M, Rice R . Persistence of Neisseria gonorrhoeae strains with decreased susceptibilities to ciprofloxacin and ofloxacin in Cleveland, Ohio, from 1992 through 1993. Antimicrob Agents Chemother. 1994; 38(9):2194-6. PMC: 284710. DOI: 10.1128/AAC.38.9.2194. View

13.

Deguchi T, Saito I, Tanaka M, Sato K, Deguchi K, Yasuda M . Fluoroquinolone treatment failure in gonorrhea. Emergence of a Neisseria gonorrhoeae strain with enhanced resistance to fluoroquinolones. Sex Transm Dis. 1997; 24(5):247-50. DOI: 10.1097/00007435-199705000-00002. View

14.

Ashford W, Golash R, Hemming V . Penicillinase-producing Neisseria gonorrhoeae. Lancet. 1976; 2(7987):657-8. DOI: 10.1016/s0140-6736(76)92467-3. View

15.

Phillips I . Beta-lactamase-producing, penicillin-resistant gonococcus. Lancet. 1976; 2(7987):656-7. DOI: 10.1016/s0140-6736(76)92466-1. View

16.

Gordon S, Mosure D, Lewis J, Brown S, McNagny S, Schmid G . Prevalence of self-medication with antibiotics among patients attending a clinic for treatment of sexually transmitted diseases. Clin Infect Dis. 1993; 17(3):462-5. DOI: 10.1093/clinids/17.3.462. View

17.

Schwarcz S, Zenilman J, Schnell D, Knapp J, Hook 3rd E, Thompson S . National surveillance of antimicrobial resistance in Neisseria gonorrhoeae. The Gonococcal Isolate Surveillance Project. JAMA. 1990; 264(11):1413-7. View

18.

Hooper D, Wolfson J, Ng E, SWARTZ M . Mechanisms of action of and resistance to ciprofloxacin. Am J Med. 1987; 82(4A):12-20. View

19.

Knapp J . Neisseria gonorrhoeae resistant to ciprofloxacin and ofloxacin. Sex Transm Dis. 1998; 25(8):425-6. DOI: 10.1097/00007435-199809000-00008. View

20.

Knapp J, Mesola V, Neal S, Wi T, Tuazon C, Manalastas R . Molecular epidemiology, in 1994, of Neisseria gonorrhoeae in Manila and Cebu City, Republic of the Philippines. Sex Transm Dis. 1997; 24(1):2-7. DOI: 10.1097/00007435-199701000-00002. View