Steroid Receptors and Metastatic Potential in Endometrial Cancers

Overview

Journal J Steroid Biochem Mol Biol

Specialties Biochemistry
Molecular Biology

Date 2001 Apr 3

PMID 11282273

Citations 4

Authors

J Fujimoto

H Sakaguchi

I Aoki

S Khatun

H Toyoki

T Tamaya

Affiliations

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Abstract

The relative overexpression of estrogen receptor (ER)-alpha exon 5 splicing variant, the disrupted synchronization of ER-beta and ER-alpha expressions, and the suppression of progesterone receptor (PR) form A expression as a transcriptional repressor might be related to metastatic potential of uterine endometrial cancers, leading to poor patient prognosis related to estrogen refractoriness.

Citing Articles

Distribution of estrogen and progesterone receptors isoforms in endometrial cancer.

Kreizman-Shefer H, Pricop J, Goldman S, Elmalah I, Shalev E Diagn Pathol. 2014; 9:77.

PMID: 24684970 PMC: 4022268. DOI: 10.1186/1746-1596-9-77.

Characterization of LHY-821, a novel moderately differentiated endometrial carcinoma cell line.

Hu Q, Yu L, Chen R, Zhang Y, Xie Y, Liao Q In Vitro Cell Dev Biol Anim. 2012; 48(7):441-8.

PMID: 22806968 DOI: 10.1007/s11626-012-9518-8.

Characterization of EN-1078D, a poorly differentiated human endometrial carcinoma cell line: a novel tool to study endometrial invasion in vitro.

Dery M, Van Themsche C, Provencher D, Mes-Masson A, Asselin E Reprod Biol Endocrinol. 2007; 5:38.

PMID: 17894888 PMC: 2092433. DOI: 10.1186/1477-7827-5-38.

Gender difference in the activity but not expression of estrogen receptors alpha and beta in human lung adenocarcinoma cells.

Dougherty S, Mazhawidza W, Bohn A, Robinson K, Mattingly K, Blankenship K Endocr Relat Cancer. 2006; 13(1):113-34.

PMID: 16601283 PMC: 1472635. DOI: 10.1677/erc.1.01118.