Dehydration of Tetracycline

Overview

Journal J Pharm Sci

Publisher Elsevier

Specialties Pharmacology
Pharmacy

Date 1975 Feb 1

PMID 1127597

Citations 7

Authors

K D Schlecht

C W Frank

Affiliations

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Abstract

The dehydration of tetracycline at the C-5a-C-6 position as a function of acidity was investigated at various temperatures. The rate was first order with respect to tetracycline and with respect to [H+]. Rate constants and an activation energy are reported. Tetracycline was unstable in dilute acid.

Citing Articles

The Assessment of Physicochemical and Antimicrobial Properties of Hydrophilic Gels Containing Tetracycline Hydrochloride and Various Concentrations of Ethanol.

Kostrzebska A, Junka A, Brozyna M, Musial W Pharmaceutics. 2024; 16(6).

PMID: 38931950 PMC: 11207367. DOI: 10.3390/pharmaceutics16060830.

Effect of Hydrogel Substrate Components on the Stability of Tetracycline Hydrochloride and Swelling Activity against Model Skin Sebum.

Kostrzebska A, Paczek K, Weselak A, Musial W Int J Mol Sci. 2023; 24(3).

PMID: 36768998 PMC: 9916833. DOI: 10.3390/ijms24032678.

Evaluation of the Influence of a Hydrogel Containing AMPD on the Stability of Tetracycline Hydrochloride.

Kostrzebska A, Zlocinska A, Musial W Pharmaceutics. 2021; 13(9).

PMID: 34575457 PMC: 8468035. DOI: 10.3390/pharmaceutics13091381.

Rapid Raman Spectroscopic Analysis of Stress Induced Degradation of the Pharmaceutical Drug Tetracycline.

Christian D, Timea F, Juergen P, Frosch T Molecules. 2020; 25(8).

PMID: 32316681 PMC: 7221697. DOI: 10.3390/molecules25081866.

pH-dependent spectroscopy of tetracycline and its analogs.

Mojica E, Nguyen E, Rozov M, Bright F J Fluoresc. 2014; 24(4):1183-98.

PMID: 24806484 DOI: 10.1007/s10895-014-1399-7.