Differences in Quantal Amplitude Reflect GluR4- Subunit Number at Corticothalamic Synapses on Two Populations of Thalamic Neurons

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2001 Mar 29

PMID 11274440

Citations 98

Authors

P Golshani

X B Liu

E G Jones

Affiliations

Soon will be listed here.

Abstract

Low-frequency thalamocortical oscillations that underlie drowsiness and slow-wave sleep depend on rhythmic inhibition of relay cells by neurons in the reticular nucleus (RTN) under the influence of corticothalamic fibers that branch to innervate RTN neurons and relay neurons. To generate oscillations, input to RTN predictably should be stronger so disynaptic inhibition of relay cells overcomes direct corticothalamic excitation. Amplitudes of excitatory postsynaptic conductances (EPSCs) evoked in RTN neurons by minimal stimulation of corticothalamic fibers were 2.4 times larger than in relay neurons, and quantal size of RTN EPSCs was 2.6 times greater. GluR4-receptor subunits labeled at corticothalamic synapses on RTN neurons outnumbered those on relay cells by 3.7 times, providing a basis for differences in synaptic strength.

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