Hepatosplenic and Subcutaneous Panniculitis-like Gamma/delta T Cell Lymphomas Are Derived from Different Vdelta Subsets of Gamma/delta T Lymphocytes

Overview

Journal J Mol Diagn

Publisher Elsevier

Specialties Molecular Biology
Pathology

Date 2001 Mar 29

PMID 11272897

Citations 20

Authors

G K Przybylski

H Wu

W R Macon

J Finan

D G Leonard

R E Felgar

J A DiGiuseppe

P C Nowell

S H Swerdlow

M E Kadin

M A Wasik

K E Salhany

Affiliations

Soon will be listed here.

Abstract

Gamma/delta T cell lymphomas (gamma/delta TCL) represent rare, often aggressive types of T cell malignancy that are clinically and pathologically diverse. Most gamma/delta TCL occur as a hepatosplenic or subcutaneous type. To date, analysis of the T cell receptor delta (TCRS) gene repertoire of hepatosplenic gamma/delta TCL (gamma/delta HSTCL) and subcutaneous panniculitis-like gamma/delta TCL (gamma/delta SPTCL) has been reported only in a limited number of cases. In this study we analyzed 11 gamma/delta HSTCL and 4 gamma/delta SPTCL by polymerase chain reaction and immunostaining to determine their usage of the Vdelta subtypes (Vdelta1-6). It is noteworthy that 10 of 11 gamma/delta HSTCL expressed the Vdelta1 gene. The remaining case also expressed T cell receptor delta (TCRS) as determined by flow cytometry and TCRdelta rearrangement in Southern blot. However, the Vdelta gene expressed by this lymphoma could not be determined, which suggests usage of an as yet unidentified Vdelta gene. In striking contrast to the gamma/delta HSTCL, all 4 gamma/delta SPTCL expressed the Vdelta2 gene. Our data demonstrate that gamma/delta HSTCL are preferentially derived from the Vdelta1 subset of gamma/delta T lymphocytes, whereas gamma/delta SPTCL are preferentially derived from the Vdelta2 subset. The pattern of Vdelta gene expression in HSTCL and SPTCL corresponds to the respective, predominant gamma/delta T cell subsets normally found in the spleen and skin. This finding suggests that gamma/delta TCL are derived from normal gamma/delta T lymphocytes which reside in the affected tissues. Furthermore, the selective, lymphoma type-specific Vdelta gene segment usage may provide a molecular tool to distinguish better among various types of gamma/delta TCL lymphoma particularly in the clinically advanced, widely disseminated cases.

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References

EDWARDS R, Wasik M, Finan J, Rodriguez R, Moore J, Kamoun M . Evidence for early hematopoietic progenitor cell involvement in acute promyelocytic leukemia. Am J Clin Pathol. 1999; 112(6):819-27. DOI: 10.1093/ajcp/112.6.819. View

McVay L, Carding S . Extrathymic origin of human gamma delta T cells during fetal development. J Immunol. 1996; 157(7):2873-82. View

Takihara Y, Tkachuk D, Michalopoulos E, Champagne E, Reimann J, Minden M . Sequence and organization of the diversity, joining, and constant region genes of the human T-cell delta-chain locus. Proc Natl Acad Sci U S A. 1988; 85(16):6097-101. PMC: 281912. DOI: 10.1073/pnas.85.16.6097. View

Takihara Y, Reimann J, Michalopoulos E, Ciccone E, Moretta L, Mak T . Diversity and structure of human T cell receptor delta chain genes in peripheral blood gamma/delta-bearing T lymphocytes. J Exp Med. 1989; 169(2):393-405. PMC: 2189221. DOI: 10.1084/jem.169.2.393. View

Falini B, Flenghi L, Pileri S, Pelicci P, Fagioli M, Martelli M . Distribution of T cells bearing different forms of the T cell receptor gamma/delta in normal and pathological human tissues. J Immunol. 1989; 143(8):2480-8. View

De Villartay J, Pullman A, Andrade R, Tschachler E, Colamenici O, Neckers L . Gamma/delta lineage relationship within a consecutive series of human precursor T-cell neoplasms. Blood. 1989; 74(7):2508-18. View

Biondi A, Francia di Celle P, Rossi V, Casorati G, Matullo G, Giudici G . High prevalence of T-cell receptor V delta 2-(D)-D delta 3 or D delta 1/2-D delta 3 rearrangements in B-precursor acute lymphoblastic leukemias. Blood. 1990; 75(9):1834-40. View

Farcet J, Gaulard P, Marolleau J, Le Couedic J, Henni T, Gourdin M . Hepatosplenic T-cell lymphoma: sinusal/sinusoidal localization of malignant cells expressing the T-cell receptor gamma delta. Blood. 1990; 75(11):2213-9. View

Gaulard P, Bourquelot P, Kanavaros P, Haioun C, Le Couedic J, Divine M . Expression of the alpha/beta and gamma/delta T-cell receptors in 57 cases of peripheral T-cell lymphomas. Identification of a subset of gamma/delta T-cell lymphomas. Am J Pathol. 1990; 137(3):617-28. PMC: 1877506. View

10.

Gonzalez C, Medeiros L, Braziel R, Jaffe E . T-cell lymphoma involving subcutaneous tissue. A clinicopathologic entity commonly associated with hemophagocytic syndrome. Am J Surg Pathol. 1991; 15(1):17-27. DOI: 10.1097/00000478-199101000-00002. View

11.

Yokota S, Hansen-Hagge T, Ludwig W, Reiter A, Raghavachar A, Kleihauer E . Use of polymerase chain reactions to monitor minimal residual disease in acute lymphoblastic leukemia patients. Blood. 1991; 77(2):331-9. View

12.

Bandeira A, Itohara S, Bonneville M, Coutinho A, Tonegawa S . Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor gamma delta. Proc Natl Acad Sci U S A. 1991; 88(1):43-7. PMC: 50744. DOI: 10.1073/pnas.88.1.43. View

13.

Palacios R, Samaridis J . Rearrangement patterns of T-cell receptor genes in the spleen of athymic (nu/nu) young mice. Immunogenetics. 1991; 33(2):90-5. DOI: 10.1007/BF00210820. View

14.

Gaulard P, Kanavaros P, Farcet J, Rocha F, Haioun C, Divine M . Bone marrow histologic and immunohistochemical findings in peripheral. T-cell lymphoma: A study of 38 cases. Hum Pathol. 1991; 22(4):331-8. DOI: 10.1016/0046-8177(91)90081-y. View

15.

Burg G, Dummer R, Wilhelm M, Nestle F, Ott M, Feller A . A subcutaneous delta-positive T-cell lymphoma that produces interferon gamma. N Engl J Med. 1991; 325(15):1078-81. DOI: 10.1056/NEJM199110103251506. View

16.

Correa I, Bix M, Liao N, Zijlstra M, Jaenisch R, Raulet D . Most gamma delta T cells develop normally in beta 2-microglobulin-deficient mice. Proc Natl Acad Sci U S A. 1992; 89(2):653-7. PMC: 48297. DOI: 10.1073/pnas.89.2.653. View

17.

Ota Y, Kobata T, Seki M, Yagita H, Shimada S, Huang Y . Extrathymic origin of V gamma 1/V delta 6 T cells in the skin. Eur J Immunol. 1992; 22(2):595-8. DOI: 10.1002/eji.1830220245. View

18.

Fujita M, Miyachi Y, Furukawa F, Toichi E, Furukawa I, Nakajima N . A case of cutaneous T-cell lymphoma expressing gamma delta T-cell receptors. J Am Acad Dermatol. 1993; 28(2 Pt 2):355-60. DOI: 10.1016/0190-9622(93)70054-w. View

19.

Haas W, Pereira P, Tonegawa S . Gamma/delta cells. Annu Rev Immunol. 1993; 11:637-85. DOI: 10.1146/annurev.iy.11.040193.003225. View

20.

Ohno T, Komada F, Yamaguchi M, Oka K, Nishii K, Tsuda M . Gamma/delta T-cell lymphoma with hepatosplenomegaly: report of a case. Int J Hematol. 1993; 57(3):269-76. View