Optimisation of Cyclotron Production Parameters for the 209Bi(alpha, 2n) 211At Reaction Related to Biomedical Use of 211At

Overview

Journal Appl Radiat Isot

Specialties Environmental Health
Nuclear Medicine

Date 2001 Mar 22

PMID 11258534

Citations 6

Authors

G Henriksen

S Messelt

E Olsen

R H Larsen

Affiliations

Soon will be listed here.

Abstract

The cyclotron alpha beam production of 211At and of the contaminant 210At related to beam energy were studied. Radiochemical purification of 211At from the other main contaminant, 210Po, by an extraction procedure was also evaluated. To avoid impurities 28MeV has previously been considered as a maximum beam energy, but by using instead 29.1 MeV as a limit a large increase in EOB yield and sufficient radiochemical purity of extracted 211At were obtained. More cyclotrons could thereby deliver quantities useful for clinical cancer trials.

Citing Articles

Production of [At]NaAt solution under GMP compliance for investigator-initiated clinical trial.

Naka S, Ooe K, Shirakami Y, Kurimoto K, Sakai T, Takahashi K EJNMMI Radiopharm Chem. 2024; 9(1):29.

PMID: 38619655 PMC: 11018728. DOI: 10.1186/s41181-024-00257-z.

Alpha Particle-Emitting Radiopharmaceuticals as Cancer Therapy: Biological Basis, Current Status, and Future Outlook for Therapeutics Discovery.

Coll R, Bright S, Martinus D, Georgiou D, Sawakuchi G, Manning H Mol Imaging Biol. 2023; 25(6):991-1019.

PMID: 37845582 DOI: 10.1007/s11307-023-01857-y.

Production, purification and availability of At: Near term steps towards global access.

Feng Y, Zalutsky M Nucl Med Biol. 2021; 100-101:12-23.

PMID: 34144505 PMC: 8448941. DOI: 10.1016/j.nucmedbio.2021.05.007.

Targeted α-therapy of prostate cancer using radiolabeled PSMA inhibitors: a game changer in nuclear medicine.

Chakravarty R, Siamof C, Dash A, Cai W Am J Nucl Med Mol Imaging. 2018; 8(4):247-267.

PMID: 30245917 PMC: 6146164.

Astatine-211: production and availability.

Zalutsky M, Pruszynski M Curr Radiopharm. 2011; 4(3):177-85.

PMID: 22201707 PMC: 3503149. DOI: 10.2174/1874471011104030177.