Physiology of Angiogenesis

Overview

Journal J Neurooncol

Publisher Springer

Date 2001 Mar 14

PMID 11245276

Citations 20

Authors

H Kurz

Affiliations

Soon will be listed here.

Abstract

Angiogenesis is a key prerequisite for growth in all vertebrate embryos and in many tumors. Rapid growth requires efficient transport of oxygen and metabolites. Hence, for a better understanding of tissue growth, biophysical properties of vascular systems, in addition to their molecular mechanisms, need to be investigated. The purpose of this article is twofold: (1) to discuss the biophysics of growing and perfused vascular systems in general, emphasizing non-sprouting angiogenesis and remodeling of vascular plexuses; and (2) to report on cellular details of sprouting angiogenesis in the initially non-perfused embryonic brain and spinal cord. It is concluded that (1) evolutionary optimization of the circulatory system corresponds to highly conserved vascular patterns and angiogenetic mechanisms; (2) deterministic and random processes contribute to both extraembryonic and central nervous system vascularization; (3) endothelial cells interact with a variety of periendothelial cells during angiogenesis and remodeling; and that (4) mathematical models integrating molecular, morphological and biophysical expertise improve our understanding of normal and pathological angiogenesis and account for allometric relations.

Citing Articles

Phloridzin Docosahexaenoate, an Omega-3 Fatty Acid Ester of a Flavonoid Precursor, Inhibits Angiogenesis by Suppressing Endothelial Cell Proliferation, Migration, and Differentiation.

Fernando W, MacLean E, Monro S, Power Coombs M, Marcato P, Rupasinghe H Biomolecules. 2024; 14(7).

PMID: 39062483 PMC: 11274491. DOI: 10.3390/biom14070769.

Developmental Associations between Neurovascularization and Microglia Colonization.

Harry G Int J Mol Sci. 2024; 25(2).

PMID: 38279280 PMC: 10816009. DOI: 10.3390/ijms25021281.

Vein fate determined by flow-based but time-delayed integration of network architecture.

Marbach S, Ziethen N, Bastin L, Bauerle F, Alim K Elife. 2023; 12.

PMID: 36916885 PMC: 10234634. DOI: 10.7554/eLife.78100.

A Metabolic Signature to Monitor Endothelial Cell Differentiation, Activation, and Vascular Organization.

Lopes-Coelho F, Martins F, Hipolito A, Conde S, Pereira S, Goncalves L Biomedicines. 2022; 10(9).

PMID: 36140393 PMC: 9496047. DOI: 10.3390/biomedicines10092293.

An Update on the Potential Application of Herbal Medicine in Promoting Angiogenesis.

Li J, Li R, Wu X, Zheng C, Shiu P, Rangsinth P Front Pharmacol. 2022; 13:928817.

PMID: 35928282 PMC: 9345329. DOI: 10.3389/fphar.2022.928817.

References

Segal S . Cell-to-cell communication coordinates blood flow control. Hypertension. 1994; 23(6 Pt 2):1113-20. DOI: 10.1161/01.hyp.23.6.1113. View

Kurz H, Sandau K, Christ B . On the bifurcation of blood vessels--Wilhelm Roux's doctoral thesis (Jena 1878)--a seminal work for biophysical modelling in developmental biology. Ann Anat. 1997; 179(1):33-6. DOI: 10.1016/S0940-9602(97)80132-X. View

Ehler E, Karlhuber G, Bauer H, Draeger A . Heterogeneity of smooth muscle-associated proteins in mammalian brain microvasculature. Cell Tissue Res. 1995; 279(2):393-403. DOI: 10.1007/BF00318497. View

Wilms P, Christ B, Wilting J, Wachtler F . Distribution and migration of angiogenic cells from grafted avascular intraembryonic mesoderm. Anat Embryol (Berl). 1991; 183(4):371-7. DOI: 10.1007/BF00196838. View

Adam P, Clesham G, Weissberg P . Expression of endoglin mRNA and protein in human vascular smooth muscle cells. Biochem Biophys Res Commun. 1998; 247(1):33-7. DOI: 10.1006/bbrc.1998.8734. View

Burri P, Tarek M . A novel mechanism of capillary growth in the rat pulmonary microcirculation. Anat Rec. 1990; 228(1):35-45. DOI: 10.1002/ar.1092280107. View

Wolff J, Bar T . 'Seamless' endothelia in brain capillaries during development of the rat's cerebral cortex. Brain Res. 1972; 41(1):17-24. DOI: 10.1016/0006-8993(72)90613-0. View

Benjamin L, Golijanin D, Itin A, Pode D, Keshet E . Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest. 1999; 103(2):159-65. PMC: 407882. DOI: 10.1172/JCI5028. View

Forsyth P, Wong H, Laing T, Rewcastle N, Morris D, Muzik H . Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas. Br J Cancer. 1999; 79(11-12):1828-35. PMC: 2362801. DOI: 10.1038/sj.bjc.6690291. View

10.

VAN MIEROP L, Bertuch Jr C . Development of arterial blood pressure in the chick embryo. Am J Physiol. 1967; 212(1):43-8. DOI: 10.1152/ajplegacy.1967.212.1.43. View

11.

Lindahl P, Johansson B, Leveen P, Betsholtz C . Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science. 1997; 277(5323):242-5. DOI: 10.1126/science.277.5323.242. View

12.

Moore S, Thanos S . The concept of microglia in relation to central nervous system disease and regeneration. Prog Neurobiol. 1996; 48(4-5):441-60. DOI: 10.1016/0301-0082(95)00051-8. View

13.

Patan S, Alvarez M, Schittny J, Burri P . Intussusceptive microvascular growth: a common alternative to capillary sprouting. Arch Histol Cytol. 1992; 55 Suppl:65-75. DOI: 10.1679/aohc.55.suppl_65. View

14.

Lyden D, Young A, Zagzag D, Yan W, Gerald W, OReilly R . Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Nature. 1999; 401(6754):670-7. DOI: 10.1038/44334. View

15.

Somlyo A, Somlyo A . Signal transduction and regulation in smooth muscle. Nature. 1994; 372(6503):231-6. DOI: 10.1038/372231a0. View

16.

Roncali L, Virgintino D, Coltey P, Bertossi M, Errede M, Ribatti D . Morphological aspects of the vascularization in intraventricular neural transplants from embryo to embryo. Anat Embryol (Berl). 1996; 193(3):191-203. DOI: 10.1007/BF00198323. View

17.

Christ B, Schmidt C, Huang R, Wilting J, Brand-Saberi B . Segmentation of the vertebrate body. Anat Embryol (Berl). 1998; 197(1):1-8. DOI: 10.1007/s004290050116. View

18.

Spatz H . Circulation, metabolic rate, and body size in mammals. J Comp Physiol B. 1991; 161(3):231-6. DOI: 10.1007/BF00262303. View

19.

Pries A, Secomb T, Gaehtgens P . Structural adaptation and stability of microvascular networks: theory and simulations. Am J Physiol. 1998; 275(2):H349-60. DOI: 10.1152/ajpheart.1998.275.2.H349. View

20.

Andjelkovic A, Nikolic B, Pachter J, Zecevic N . Macrophages/microglial cells in human central nervous system during development: an immunohistochemical study. Brain Res. 1998; 814(1-2):13-25. DOI: 10.1016/s0006-8993(98)00830-0. View