» Articles » PMID: 11217791

Estimating the Precision of Exact Mass Measurements on an Orthogonal Time-of-flight Mass Spectrometer

Overview
Journal Anal Chem
Specialty Chemistry
Date 2001 Feb 24
PMID 11217791
Citations 8
Authors
Affiliations
Soon will be listed here.
Abstract

The combination of orthogonal TOF/ESI MS exact mass measurement and on-line chromatography represents a powerful analytical tool for identifying unknown components in complex mixtures and is being widely utilized. The precision of these mass data is often incorrectly estimated as the precision or mean deviation obtained for reference standards under standard conditions. But, the precision of a mass measurement is dependent on the number of ions sampled in the measurement and, thus, is likely to be different for every measurement. A simple procedure for correctly estimating the precision of a specific mass measurement is presented, the limits of the procedure are investigated, and the utility and validity of the procedure are demonstrated.

Citing Articles

Identification by Liquid Chromatography-Tandem Mass Spectrometry and Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry of the Contributor to the Thyroid Hormone Receptor Agonist Activity in Effluents from Sewage Treatment Plants.

Omagari R, Yagishita M, Shiraishi F, Nakayama S, Terasaki M, Tanigawa T Environ Sci Technol. 2022; 56(19):13709-13718.

PMID: 36100216 PMC: 9536310. DOI: 10.1021/acs.est.2c02648.


An algorithm to correct saturated mass spectrometry ion abundances for enhanced quantitation and mass accuracy in omic studies.

Bilbao A, Gibbons B, Slysz G, Crowell K, Monroe M, Ibrahim Y Int J Mass Spectrom. 2018; 427:91-99.

PMID: 29706793 PMC: 5920534. DOI: 10.1016/j.ijms.2017.11.003.


Bioinformatics Tools for Mass Spectroscopy-Based Metabolomic Data Processing and Analysis.

Sugimoto M, Kawakami M, Robert M, Soga T, Tomita M Curr Bioinform. 2012; 7(1):96-108.

PMID: 22438836 PMC: 3299976. DOI: 10.2174/157489312799304431.


Full-scan accurate mass selectivity of ultra-performance liquid chromatography combined with time-of-flight and orbitrap mass spectrometry in hormone and veterinary drug residue analysis.

van der Heeft E, Bolck Y, Beumer B, Nijrolder A, Stolker A, Nielen M J Am Soc Mass Spectrom. 2008; 20(3):451-63.

PMID: 19101163 DOI: 10.1016/j.jasms.2008.11.002.


Accurate mass measurements in proteomics.

Liu T, Belov M, Jaitly N, Qian W, Smith R Chem Rev. 2007; 107(8):3621-53.

PMID: 17649984 PMC: 2713049. DOI: 10.1021/cr068288j.