Characteristics of Cryopreserved Semen from Men with Lymphoma

Overview

Journal J Assist Reprod Genet

Publisher Springer

Specialties Genetics
Reproductive Medicine

Date 2001 Feb 24

PMID 11209541

Citations 7

Authors

J Hallak

A M Mahran

A Agarwal

Affiliations

Soon will be listed here.

Abstract

Purpose: This study compared the pretreatment semen quality in patients with Hodgkin's disease and non-Hodgkin's lymphoma with a group of healthy donors. We also examined the differences in prefreeze and postthaw semen quality among the different stages of Hodgkin's disease.

Methods: The study included 89 patients with Hodgkin's disease, 18 with non-Hodgkin's lymphoma, and 50 healthy sperm donors.

Results: In patients with Hodgkin's disease, the prefreeze and postthaw semen characteristics were significantly lower than those of the healthy donors. Similar results also were seen in patients with non-Hodgkin's lymphoma. No significant differences in the prefreeze semen quality were seen in patients with different stages of cancer.

Conclusion: Patients with Hodgkin's disease and non-Hodgkin's lymphoma in our study had poor semen quality when compared with healthy donors both before and after cryopreservation. As cancer therapy significantly impairs reproductive potential, sperm banking should be offered to these men before the start of their therapy.

Citing Articles

Reproductive ability in survivors of childhood, adolescent, and young adult Hodgkin lymphoma: a review.

Drechsel K, Pilon M, Stoutjesdijk F, Meivis S, Schoonmade L, Wallace W Hum Reprod Update. 2023; 29(4):486-517.

PMID: 36779325 PMC: 10320502. DOI: 10.1093/humupd/dmad002.

Paternity through use of assisted reproduction technology in male adult and childhood cancer survivors: a nationwide register study.

Kitlinski M, Giwercman A, Elenkov A Hum Reprod. 2023; 38(5):973-981.

PMID: 36773319 PMC: 10228784. DOI: 10.1093/humrep/dead026.

Long-term sperm cryopreservation does not affect post-thaw survival rates.

Pariz J, Monteiro R, Hallak J JBRA Assist Reprod. 2019; 24(1):3-8.

PMID: 31689041 PMC: 6993159. DOI: 10.5935/1518-0557.20190066.

Fertility preservation practices in pediatric and adolescent cancer patients undergoing HSCT in Europe: a population-based survey.

Diesch T, Rovo A, von der Weid N, Faraci M, Pillon M, Dalissier A Bone Marrow Transplant. 2017; 52(7):1022-1028.

PMID: 28112743 DOI: 10.1038/bmt.2016.363.

Fertility-preserving treatment options in patients with malignant hematological diseases.

Kucuk M, Bolaman A, Yavasoglu I, Kadikoylu G Turk J Haematol. 2014; 29(3):207-16.

PMID: 24744663 PMC: 3986744. DOI: 10.5505/tjh.2012.72681.

References

Sherins R, Thorsell L, Dorfmann A, Calvo L, Krysa L, Coulam C . Intracytoplasmic sperm injection facilitates fertilization even in the most severe forms of male infertility: pregnancy outcome correlates with maternal age and number of eggs available. Fertil Steril. 1995; 64(2):369-75. DOI: 10.1016/s0015-0282(16)57737-1. View

Shekarriz M, Tolentino Jr M, Ayzman I, Lee J, Thomas Jr A, Agarwal A . Cryopreservation and semen quality in patients with Hodgkin's disease. Cancer. 1995; 75(11):2732-6. DOI: 10.1002/1097-0142(19950601)75:11<2732::aid-cncr2820751116>3.0.co;2-s. View

Agarwal A, Shekarriz M, Sidhu R, Thomas Jr A . Value of clinical diagnosis in predicting the quality of cryopreserved sperm from cancer patients. J Urol. 1996; 155(3):934-8. View

Shaw J, Bowles J, Koopman P, Wood E, Trounson A . Fresh and cryopreserved ovarian tissue samples from donors with lymphoma transmit the cancer to graft recipients. Hum Reprod. 1996; 11(8):1668-73. DOI: 10.1093/oxfordjournals.humrep.a019467. View

Padron O, Sharma R, Thomas Jr A, Agarwal A . Effects of cancer on spermatozoa quality after cryopreservation: a 12-year experience. Fertil Steril. 1997; 67(2):326-31. DOI: 10.1016/S0015-0282(97)81919-X. View

Botchan A, Hauser R, Gamzu R, Yogev L, Lessing J, Paz G . Sperm quality in Hodgkin's disease versus non-Hodgkin's lymphoma. Hum Reprod. 1997; 12(1):73-6. DOI: 10.1093/humrep/12.1.73. View

Marmor D, Duyck F . Male reproductive potential after MOPP therapy for Hodgkin's disease: a long-term survey. Andrologia. 1995; 27(2):99-106. DOI: 10.1111/j.1439-0272.1995.tb01078.x. View

Whitehead E, Shalet S, Blackledge G, Todd I, Crowther D, Beardwell C . The effects of Hodgkin's disease and combination chemotherapy on gonadal function in the adult male. Cancer. 1982; 49(3):418-22. DOI: 10.1002/1097-0142(19820201)49:3<418::aid-cncr2820490304>3.0.co;2-a. View

Berthelsen J, Skakkebaek N . Gonadal function in men with testis cancer. Fertil Steril. 1983; 39(1):68-75. View

10.

Kaempfer S, Hoffman D, Wiley F . Sperm banking: a reproductive option in cancer therapy. Cancer Nurs. 1983; 6(1):31-8. View

11.

HENDRY W, Stedronska J, Jones C, Blackmore C, Barrett A, Peckham M . Semen analysis in testicular cancer and Hodgkin's disease: pre- and post-treatment findings and implications for cryopreservation. Br J Urol. 1983; 55(6):769-73. DOI: 10.1111/j.1464-410x.1983.tb03423.x. View

12.

Parvinen M, Lahdetie J, Parvinen L . Toxic and mutagenic influences on spermatogenesis. Arch Toxicol Suppl. 1984; 7:128-39. DOI: 10.1007/978-3-642-69132-4_15. View

13.

Berthelsen J . Testicular cancer and fertility. Int J Androl. 1987; 10(1):371-80. DOI: 10.1111/j.1365-2605.1987.tb00205.x. View

14.

Lister T, Crowther D, Sutcliffe S, Glatstein E, Canellos G, Young R . Report of a committee convened to discuss the evaluation and staging of patients with Hodgkin's disease: Cotswolds meeting. J Clin Oncol. 1989; 7(11):1630-6. DOI: 10.1200/JCO.1989.7.11.1630. View

15.

Milligan D, Hughes R, Lindsay K . Semen cryopreservation in men undergoing cancer chemotherapy--a UK survey. Br J Cancer. 1989; 60(6):966-7. PMC: 2247267. DOI: 10.1038/bjc.1989.399. View

16.

Fossa S, Theodorsen L, Norman N, Aabyholm T . Recovery of impaired pretreatment spermatogenesis in testicular cancer. Fertil Steril. 1990; 54(3):493-6. DOI: 10.1016/s0015-0282(16)53768-6. View

17.

Viviani S, Ragni G, Santoro A, Perotti L, Caccamo E, Negretti E . Testicular dysfunction in Hodgkin's disease before and after treatment. Eur J Cancer. 1991; 27(11):1389-92. DOI: 10.1016/0277-5379(91)90017-8. View

18.

Khalifa E, Oehninger S, Acosta A, Morshedi M, Veeck L, Bryzyski R . Successful fertilization and pregnancy outcome in in-vitro fertilization using cryopreserved/thawed spermatozoa from patients with malignant diseases. Hum Reprod. 1992; 7(1):105-8. DOI: 10.1093/oxfordjournals.humrep.a137539. View

19.

Levron J, Lightman A, STEIN D, Brandes J, Itskovitz-Eldor J . Pregnancy after subzonal insertion of cryopreserved spermatozoa from a patient with testicular seminoma. Fertil Steril. 1992; 58(4):839-40. DOI: 10.1016/s0015-0282(16)55340-0. View

20.

Pryzant R, Meistrich M, Wilson G, Brown B, McLaughlin P . Long-term reduction in sperm count after chemotherapy with and without radiation therapy for non-Hodgkin's lymphomas. J Clin Oncol. 1993; 11(2):239-47. DOI: 10.1200/JCO.1993.11.2.239. View