Exhaled Nitric Oxide is Reduced in Infants with Cystic Fibrosis

Overview

Journal Thorax

Date 2001 Feb 24

PMID 11209106

Citations 16

Authors

H E Elphick

E A Demoncheaux

S Ritson

T W Higenbottam

M L Everard

Affiliations

Soon will be listed here.

Abstract

Background: Exhaled nitric oxide levels are low in patients with cystic fibrosis (CF), despite the chronic inflammation present in the airways. This study aimed to determine whether levels of exhaled nitric oxide were reduced prior to the onset of respiratory symptoms in infants with CF.

Methods: The levels of exhaled nitric oxide were measured using a chemiluminescence analyser in five infants with CF and 11 healthy control subjects, both groups having a mean age of 48.6 days.

Results: Mean levels of exhaled nitric oxide were significantly lower in infants with CF than in the control group (4.9 ppb v 12.1 ppb; p=0.01).

Conclusions: This finding may be the key to understanding the inflammatory processes in early cystic fibrosis and may lead to novel treatment approaches.

Citing Articles

Effects of quorum sensing-interfering agents, including macrolides and furanone C-30, and an efflux pump inhibitor on nitrosative stress sensitivity in .

Suzuki S, Morita Y, Ishige S, Kai K, Kawasaki K, Matsushita K Microbiology (Reading). 2024; 170(6).

PMID: 38900549 PMC: 11263931. DOI: 10.1099/mic.0.001464.

The association of exhaled nitric oxide with air pollutants in young infants of asthmatic mothers.

Percival E, Collison A, Da Silva Sena C, De Queiroz Andrade E, de Gouveia Belinelo P, Martins Costa Gomes G Environ Health. 2023; 22(1):84.

PMID: 38049853 PMC: 10696885. DOI: 10.1186/s12940-023-01030-6.

Cohort profile: the vitamin A and D and nitric oxide (AD-ON) observational cohort on lung development and symptoms in premature and mature children in North Zealand, Denmark.

Goth F, Schmidt B, Juul K, Albertsen P, Agertoft L, Jorgensen I BMJ Open. 2022; 12(2):e054952.

PMID: 35193916 PMC: 8867307. DOI: 10.1136/bmjopen-2021-054952.

NO donors and NO delivery methods for controlling biofilms in chronic lung infections.

Cai Y, Zhang Y, Yang L Appl Microbiol Biotechnol. 2021; 105(10):3931-3954.

PMID: 33937932 PMC: 8140970. DOI: 10.1007/s00253-021-11274-2.

Arginine Therapy for Lung Diseases.

Scott J, Maarsingh H, Holguin F, Grasemann H Front Pharmacol. 2021; 12:627503.

PMID: 33833679 PMC: 8022134. DOI: 10.3389/fphar.2021.627503.

References

Steagall W, Elmer H, Brady K, Kelley T . Cystic fibrosis transmembrane conductance regulator-dependent regulation of epithelial inducible nitric oxide synthase expression. Am J Respir Cell Mol Biol. 1999; 22(1):45-50. DOI: 10.1165/ajrcmb.22.1.3789. View

Ho L, Innes J, Greening A . Nitrite levels in breath condensate of patients with cystic fibrosis is elevated in contrast to exhaled nitric oxide. Thorax. 1998; 53(8):680-4. PMC: 1745284. DOI: 10.1136/thx.53.8.680. View

Lundberg J, Nordvall S, Weitzberg E, Kollberg H, Alving K . Exhaled nitric oxide in paediatric asthma and cystic fibrosis. Arch Dis Child. 1996; 75(4):323-6. PMC: 1511735. DOI: 10.1136/adc.75.4.323. View

Khan T, Wagener J, Bost T, Martinez J, Accurso F, Riches D . Early pulmonary inflammation in infants with cystic fibrosis. Am J Respir Crit Care Med. 1995; 151(4):1075-82. DOI: 10.1164/ajrccm/151.4.1075. View