» Articles » PMID: 11182314

Locked Nucleic Acid (LNA): Fine-tuning the Recognition of DNA and RNA

Overview
Journal Chem Biol
Publisher Elsevier
Date 2001 Feb 22
PMID 11182314
Citations 197
Authors
Affiliations
Soon will be listed here.
Abstract

Locked nucleic acid is an RNA derivative in which the ribose ring is constrained by a methylene linkage between the 2'-oxygen and the 4'-carbon. This conformation restriction increases binding affinity for complementarity sequences and provides an exciting new chemical approach for the control of gene expression and optimization of microarrays.

Citing Articles

Modulating gene expression as a strategy to investigate thyroid cancer biology.

de Mello D, Menezes J, de Oliveira A, Cristovao M, Kimura E, Fuziwara C Arch Endocrinol Metab. 2025; 68(Spec Issue):e240073.

PMID: 39876973 PMC: 11771757. DOI: 10.20945/2359-4292-2024-0073.


Clinical Applications of Antisense Oligonucleotides in Cancer: A Focus on Glioblastoma.

Khuu A, Verreault M, Colin P, Tran H, Idbaih A Cells. 2024; 13(22).

PMID: 39594617 PMC: 11592788. DOI: 10.3390/cells13221869.


CRISPR-AsCas12f1 couples out-of-protospacer DNA unwinding with exonuclease activity in the sequential target cleavage.

Song X, Chen Z, Sun W, Yang H, Guo L, Zhao Y Nucleic Acids Res. 2024; 52(22):14030-14042.

PMID: 39530229 PMC: 11662939. DOI: 10.1093/nar/gkae989.


Development of bioconjugate-based delivery systems for nucleic acids.

Wahane A, Kasina V, Pathuri M, Marro-Wilson C, Gupta A, Slack F RNA. 2024; 31(1):1-13.

PMID: 39477529 PMC: 11648935. DOI: 10.1261/rna.080273.124.


A sperm-enriched 5'fragment of tRNA-Valine regulates preimplantation embryonic transcriptome and development.

Liu S, Holmes A, Katzman S, Sharma U bioRxiv. 2024; .

PMID: 39211093 PMC: 11361008. DOI: 10.1101/2024.08.08.607197.