Novel Nuclear Signaling Pathway Mediates Activation of Fibroblast Growth Factor-2 Gene by Type 1 and Type 2 Angiotensin II Receptors

Overview

Journal Mol Biol Cell

Specialties Cell Biology
Molecular Biology

Date 2001 Feb 17

PMID 11179427

Citations 34

Authors

H Peng

J Moffett

J Myers

X Fang

E K Stachowiak

P Maher

E Kratz

J Hines

S J Fluharty

E Mizukoshi

D C Bloom

M K Stachowiak

Affiliations

Soon will be listed here.

Abstract

In bovine adrenal medullary cells synergistically acting type 1 and type 2 angiotensin II (AII) receptors activate the fibroblast growth factor-2 (FGF-2) gene through a unique AII-responsive promoter element. Both the type 1 and type 2 AII receptors and the downstream cyclic adenosine 1',3'-monophosphate- and protein kinase C-dependent signaling pathways activate the FGF-2 promoter through a novel signal-transducing mechanism. This mechanism, which we have named integrative nuclear FGF receptor-1 signaling, involves the nuclear translocation of FGF receptor-1 and its subsequent transactivation of the AII-responsive element in the FGF-2 promoter.

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