Dependence of Lymphopenia-induced T Cell Proliferation on the Abundance of Peptide/ MHC Epitopes and Strength of Their Interaction with T Cell Receptors

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2001 Feb 15

PMID 11172019

Citations 50

Authors

Q Ge

V P Rao

B K Cho

H N Eisen

J Chen

Affiliations

Soon will be listed here.

Abstract

Factors that affect naive T cell proliferation in syngeneic lymphopenic hosts were investigated. 2C T cell receptor (TCR) transgenic T cells lacking both CD8 and CD4 survived but hardly proliferated. Proliferation of CD8(+) 2C cells was proportional to the abundance of cognate peptide/MHC complexes and was severely inhibited by injection of anti-CD8 antibody. Weakly reactive self-peptides slightly enhanced CD8(+) 2C cell proliferation whereas a potent agonist peptide promoted much more rapid proliferation, but inflammation-stimulating adjuvant had only a small effect on the rate of cell proliferation. The findings suggest that under uniform lymphopenic conditions, the widely different rates of proliferation of T cells expressing various TCR, or the same TCR in the presence or absence of CD8, reflect the strength of interaction between TCR and MHC associated with particular self-peptides.

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