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Orexin A Excites Serotonergic Neurons in the Dorsal Raphe Nucleus of the Rat

Overview
Specialties Neurology
Pharmacology
Date 2001 Feb 13
PMID 11166339
Citations 92
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Abstract

Orexin A (10-300 nM) strongly excited dorsal raphe serotonergic neurons maintained in vitro. The depolarization persisted in the presence of tetrodotoxin (TTX, 0.5 microM) and was associated with an increase in input resistance. These results have relevance in the context of food intake regulation and the disease, narcolepsy.

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