Conformational Changes During Kinesin Motility

Overview

Journal Curr Opin Cell Biol

Publisher Elsevier

Specialty Cell Biology

Date 2001 Feb 13

PMID 11163129

Citations 39

Authors

W R Schief

J Howard

Affiliations

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Abstract

Nucleotide-dependent movements of the head and neck of kinesin have been visualized by cryoelectron microscopy and have been inferred from single-molecule studies. Key predictions of the hand-over-hand model for dimeric kinesin have been confirmed, and a novel processivity mechanism for the one-headed, kinesin-related motor KIF1A has been discovered.

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Intracellular functions and motile properties of bi-directional kinesin-5 Cin8 are regulated by neck linker docking.

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