MRI Measurement of Brain Iron in Patients with Restless Legs Syndrome

Overview

Journal Neurology

Specialty Neurology

Date 2001 Feb 13

PMID 11160969

Citations 134

Authors

R P Allen

P B Barker

F W Wehrl

F Wehrl

H K Song

C J Earley

Affiliations

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Abstract

Brain iron insufficiency in the restless legs syndrome (RLS) has been suggested by a prior CSF study. Using a special MRI measurement (R2'), the authors assessed regional brain iron concentrations in 10 subjects (five with RLS, five controls). R2' was significantly decreased in the substantia nigra, and somewhat less significantly in the putamen, both in proportion to RLS severity. The results show the potential utility of this MRI measurement, and also indicate that brain iron insufficiency may occur in patients with RLS in some brain regions.

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