Anisotropy of Fluctuation Dynamics of Proteins with an Elastic Network Model

Overview

Journal Biophys J

Publisher Cell Press

Specialty Biophysics

Date 2001 Feb 13

PMID 11159421

Citations 650

Authors

A R Atilgan

S R Durell

R L Jernigan

M C Demirel

O Keskin

I Bahar

Affiliations

Soon will be listed here.

Abstract

Fluctuations about the native conformation of proteins have proven to be suitably reproduced with a simple elastic network model, which has shown excellent agreement with a number of different properties for a wide variety of proteins. This scalar model simply investigates the magnitudes of motion of individual residues in the structure. To use the elastic model approach further for developing the details of protein mechanisms, it becomes essential to expand this model to include the added details of the directions of individual residue fluctuations. In this paper a new tool is presented for this purpose and applied to the retinol-binding protein, which indicates enhanced flexibility in the region of entry to the ligand binding site and for the portion of the protein binding to its carrier protein.

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